Clinical Management; Diagnostics and Laboratory Issues; Immunology and VaccinesCenters for Disease Control and Prevention Syphilis Summit: Difficult Clinical and Patient Management IssuesMarra, Christina M. MD*; Ghanem, Khalil G. MD, PhD†Author Information From the *University of Washington School of Medicine, Seattle, WA; and †Johns Hopkins University School of Medicine, Baltimore, MD Conflict of Interest and Sources of Funding: None declared. Correspondence: Christina Marra, MD, Harborview Medical Center, Box 359775, 325 9th Ave, Seattle, WA 98104. E-mail: [email protected]. Received for publication January 23, 2018, and accepted April 2, 2018. Sexually Transmitted Diseases: September 2018 - Volume 45 - Issue 9S - p S10-S12 doi: 10.1097/OLQ.0000000000000851 Buy Metrics Abstract Despite over a century of clinical experience in diagnosing and managing patients with syphilis, many thorny clinical questions remain unanswered. We focus on several areas of uncertainty for the clinician: the role of serologic tests in diagnosing syphilis and assessing syphilis treatment responses, and the risk of neurosyphilis and ocular syphilis in patients with syphilis. We also address whether clinical approaches should differ in patients who are, and are not, infected with HIV. The current increases in syphilis rates in the United States and elsewhere underscore our urgent need to definitively address these issues. Copyright © 2018 American Sexually Transmitted Diseases Association All rights reserved.