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Syphilis Masquerading As Mass Lesions: The Utility of Modern-Day Imaging and Molecular Sequencing in Clinical Diagnosis

Lin, Ray Junhao MBBS, MRCP(UK), MMed (Int Med); Choudhury, Saugata MBBS, FRCPA, FRCPath; Lee, Cheng Chuan MBBS, MMed (Int Med), MRCP(UK), FRCP (Edin), FAMS; Lee, Tau Hong MBBS, MRCP(UK), FAMS

Sexually Transmitted Diseases: May 2017 - Volume 44 - Issue 5 - p 303–305
doi: 10.1097/OLQ.0000000000000582
Case Report

Syphilis has been known to present in a myriad of symptoms throughout the ages, and until this day, the diagnosis remains elusive to the modern physician. We present 2 unusual cases of syphilis that posed diagnostic challenges even in the current era of new and advancing diagnostic tests.

We report 2 cases of syphilis in patients with human immunodeficiency virus infection that presented as tumor-like lesions. 16S ribosomal RNA sequencing was performed to facilitate the diagnosis.

From the *Department of Infectious Diseases, Institute of Infectious Diseases and Epidemiology, and †Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore

Conflict of interest: None declared.

Correspondence: Ray Junhao Lin, MBBS, MRCP(UK), MMed (Int Med), 11 Jalan Tan Tock Seng, Singapore 308433, Republic of Singapore. E-mail:

Received for publication September 22, 2016, and accepted December 16, 2016.

© Copyright 2017 American Sexually Transmitted Diseases Association