Among urban, primarily African American pregnant women, 74% were identified with Nugent score bacterial vaginosis (BV). All BV-associated bacteria were more prevalent among women with Nugent score BV. Bacterial vaginosis–associated bacteria 3 (BVAB3) had the highest positive predictive value, whereas Gardnerella vaginalis and Atopobium spp. had the highest sensitivity. Atopobium spp. levels had the most significant area under the curve.
High levels of Atopobium spp. were related to Nugent score bacterial vaginosis among urban, pregnant women. Levels of Atopobium spp. early in pregnancy were highly sensitive and specific for bacterial vaginosis.
From the *Departments of Obstetrics and Gynecology and †Public Health, Temple University, Philadelphia, PA; ‡Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; §Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA; and ¶Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA
Acknowledgments: The authors gratefully acknowledge and thank Jill Wadlin for laboratory technical assistance, the nurses, and nurse managers at Temple University Hospital and the Philadelphia Department of Public Health.
This work was supported by funding from the National Institute of Child Health and Human Development (R01HD038856 to D.B. Nelson).
Conflict of interest: None declared.
Correspondence: Deborah B. Nelson, PhD, Department of Public Health, College of Health Professions and Social Work, Temple University, 1301 Cecil B Moore Ave, Ritter Annex, Room 905, Philadelphia, PA 19122. E-mail: firstname.lastname@example.org.
Received for publication January 10, 2013, and accepted May 14, 2013.