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Treponema pallidum Azithromycin Resistance in Dublin, Ireland

Muldoon, Eavan G. MBBCh, MD*; Walsh, Anne MSc; Crowley, Brendan MBBCh, MD; Mulcahy, Fiona MBBCh, MD*

doi: 10.1097/OLQ.0b013e318269995f
Note

This study aimed to reassess rates of syphilis azithromycin resistance in Dublin. Of the 104 samples, 36 (34.6%) were positive for Treponema pallidum DNA by polymerase chain reaction. Thirty samples were analyzed for A2058G mutation, 29 samples sequenced. Of the 29 samples, 27 (93.1%) had the mutation. Azithromycin cannot be recommended for the treatment of syphilis in Dublin.

Dublin continues to have a very high proportion of azithromycin resistant syphilis isolates. Azithromycin cannot be recommended for syphilis treatment in those who have acquired their syphilis in Ireland.

From the Departments of *Genitourinary Medicine and Infectious Diseases, and †Microbiology St. James’s Hospital, Dublin, Ireland

The rate of azithromycin resistance in Dublin remains high. Azithromycin cannot be recommended for syphilis treatment in Dublin, or for the epidemiological treatment of syphilis.

E.G.M. conducted the laboratory work and analysis of results and provided the main text of the article. A.W. supervised the laboratory work. B.C. supervised the work and reviewed the article. F.M. was in charge of the overall project supervision and document review.

The authors declare no conflicts of interest.

Supported by the Infectious Diseases Society of Ireland Research Bursary.

Correspondence: Eavan Muldoon, MBBCh, MD, Department of Genitourinary Medicine and Infectious Diseases, St James’s Hospital, James’s St, Dublin 8, Ireland. E-mail: eavan@esatclear.ie.; or Fiona Mulcahy, Department of Genitourinary Medicine and Infectious Diseases, St James’s Hospital, James’s St, Dublin 8, Ireland. E-mail: fmulcahy@stjames.ie.

Received for publication February 1, 2012, and accepted April 17, 2012.

© Copyright 2012 American Sexually Transmitted Diseases Association