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Evaluation of Self-Collected Versus Clinician-Collected Swabs for the Detection of Chlamydia trachomatis and Neisseria gonorrhoeae Pharyngeal Infection Among Men Who Have Sex With Men

Freeman, Alexandra H. BA*†; Bernstein, Kyle T. PhD*; Kohn, Robert P. MPH*; Philip, Susan MD, MPH*; Rauch, Leah M. PHM; Klausner, Jeffrey D. MD, MPH§

doi: 10.1097/OLQ.0b013e318227713e
Note

We evaluated self-sampling to detect pharyngeal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection among men who have sex with men attending a San Francisco STD clinic. The prevalence of pharyngeal NG and CT infection was 6.7% (32/480) and 1.3% (6/480), respectively. The percent agreement between self-collected and clinician-collected NG and CT specimens using nucleic acid amplification testing was 96.6% with a κ of 0.766 (95% confidence interval: 0.653–0.879) and 99.4% with a κ of 0.766 (95% confidence interval: 0.502–1.000), respectively. Acceptability was high among participants.

Our study found excellent agreement between self-collected and clinician-collected specimens using nucleic acid amplification testing to detect pharyngeal Chlamydia trachomatis and Neisseria gonorrhoeae infection among men who have sex with men attending a San Francisco STD clinic.

From the *San Francisco Department of Public Health, STD Prevention and Control Services, San Francisco, CA; †George Washington University School of Medicine & Health Sciences, Washington, DC; ‡San Francisco Department of Public Health, Public Health Laboratory, San Francisco, CA; and §Department of Medicine, University of California, San Francisco, CA

The authors thank Dr. Kenneth A. Katz, Dr. Mark Pandori, and the San Francisco City Clinic Staff for their contributions to this manuscript.

Correspondence: Alexandra (Jana) Freeman, BA, STD Prevention and Control Services, 1360 Mission Street, Suite 401, San Francisco, CA 94103. E-mail: jana.h.freeman@gmail.com.

Received for publication March 10, 2011, and accepted June 2, 2011.

© Copyright 2011 American Sexually Transmitted Diseases Association