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Detection of Human Papillomavirus DNA on the External Genitalia of Healthy Men and Male Patients with Urethritis

Takahashi, Satoshi MD*#; Shimizu, Toshiaki MD*#; Takeyama, Kou MD*#; Kunishima, Yasuharu MD*#; Hotta, Hiroshi MD*#; Koroku, Mikio MD†#; Tanda, Hitoshi MD†#; Saka, Taketoshi MD‡#; Nishimura, Masahiro MD§#; Iwasawa, Akihiko MD∥#; Furuya, Ryoji MD¶#; Hirose, Takaoki MD¶#; Kobayashi, Intetsu PhD**; Kumamoto, Yoshiaki MD*; Tsukamoto, Taiji MD*#

Sexually Transmitted Diseases: August 2003 - Volume 30 - Issue 8 - p 629-633
doi: 10.1097/01.OLQ.0000085184.68124.B3

Background Only a few studies have been done involving detection of human papillomavirus (HPV) DNA on the external genitalia of men without genital warts, although many have been done for women. We conducted HPV DNA detection among healthy male volunteers and men with urethritis, both having no visible lesions on their external genitalia.

Goal The goal of the study was to determine the detection rate of HPV DNA in volunteers and patients with urethritis and to determine risk factor(s) for positive DNA.

Study Design This was a prospective clinical study.

Results HPV DNA was found in 1.3% of 75 volunteers and in 18.5% of 130 patients with urethritis. DNA of a high-intermediate oncogenic risk was more predominant than the low-risk type. Among various risk factors, only a history of STD was a significant factor for the positive detection of HPV DNA in multiple regression analysis.

Conclusion HPV DNA was found in patients with urethritis more frequently than in volunteers, probably because the former had higher sexual activity.

HPV DNA was detected on the external genitalia of patients with urethritis more frequently than on that of male volunteers. A history of STD was a risk factor for positive detection in men.

*Department of Urology, Sapporo Medical University School of Medicine, Sanjukai Hospital, Saka Urology Hospital, §Motomachi Urology Clinic, Iwasawa Clinic, Department of Urology, Hokkaido Health Insurance Hospital, and #SMU-Clinical Research Group for Urologic Diseases, Sapporo; and **Mitsubishi Kagaku Bio-Clinical Laboratories, Tokyo, Japan

Reprint requests: Taiji Tsukamoto, MD, Department of Urology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-Ku, Sapporo 060-8543, Japan. E-mail:

Received November 15, 2002,

revised February 11, 2003, and accepted February 18, 2003.

© Copyright 2003 American Sexually Transmitted Diseases Association