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Clinical Features ofChlamydia trachomatisRectal Infection by Serovar Among Homosexually Active Men

Boisvert, Jean-François MD, MSc*; Koutsky, Laura A. PhD*; Suchland, Robert J. BS; Stamm, Walter E. MD

Original Articles

Background and Objectives: Because C. trachomatis serovars correlate with the clinical manifestations of cervical infection, we undertook this study to determine whether clinical, behavioral, and laboratory findings correlate with C. trachomatis serovars isolated from rectal infections.

Goal of This Study: To correlate C. trachomatis serovar with signs and symptoms of rectal infection.

Study Design: A cross-sectional study of 454 men with rectal C. trachomatis infection attending an urban sexually transmitted disease (STD) clinic was undertaken. Isolates were thawed, passaged to high titer, and typed using a panel of monoclonal antibodies. Compared to men infected with B complex isolates (164), men with C complex isolates (55) were less likely to report symptoms (OR: 0.4; 95% CI: 0.1-0.8), or to have erythema, bleeding, or mucopus (OR: 0.3; 95% CI: 0.1-0.8). Among men with inclusion counts of more than 100, those infected with FG group versus B complex isolates were more likely to present with mucopus (OR: 10.5; 95% CI: 1.2-95.5), more than 15 polymorphonuclear leukocytes (OR: 19.2; 95% CI: 1.7-219.8), and proctitis (OR: 4.2; 95% CI: 1.1-16.7).

Conclusion: Signs and symptoms of rectal infection correlate with the serovar of C. trachomatis isolates.

*From the Departments of Epidemiology and †Medicine, University of Washington, Seattle, Washington

Dr. J-F Boisvert was supported by the Fonds de la Recherche en Santé du Québec.

Presented in part at the 32nd Interscience Conference on Antimicrobial Agents and Chemotherapy, Anaheim, California, October 1992 (abstract 928).

J.-F. Boisvert is now at Service de microbiologie et maladies infectieuses, Centre Hospitalier Affilié Universitaire de Québec, Pavillon Saint-Sacrement, Québec, Québec, G1S 4L8, Canada.

Reprint requests: Laura A. Koutsky, Ph.D., Department of Epidemiology, Box 359933, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195.

Received for publication November 19, 1998, revised March 11, 1999, accepted March 30, 1999.

© Copyright 1999 American Sexually Transmitted Diseases Association