Oral Carbenicillin Treatment of Uncomplicated Gonorrhea in Men and Women

Abstract

In a prospective controlled study of 290 men and women with uncomplicated gonorrhea, carbenicillin was shown to be less than 90% effective. Positive cultures were the basis for initial diagnosis and therapeutic failure in both sexes. Carbenicillin was evaluated in three different schedules: 5 gm p.o., 10 gm p.o., and 2 gm IM plus 5 gm p.0. The three schedules were equally effective. Eleven of 20 failures in women occurred in infection of the rectum. MlCs of carbenicillin ranged from 0.025% to 1.0μg/ml with a mean of 0.29μg/ml.