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MRI and Body Fluid Analysis: New Means to Monitor Early Structural and Metabolic Changes in Joint Cartilage Disease

Dahlberg, Leif M.D., Ph.D.

Section Editor(s): Gillquist, Jan M.D.

Sports Medicine and Arthroscopy Review: September 2002 - Volume 10 - Issue 3 - p 214-219
Hip Injuries in the Athlete: Article

Emerging knowledge of cartilage metabolism and structure has stimulated efforts to develop new cartilage-monitoring techniques in health and disease. This article gives an overview of cartilage matrix structure, cartilage metabolism, and significant exogenous factors to show how such knowledge can guide the development of new means to monitor cartilage.

Delayed contrast enhanced MRI of cartilage (dGEMRIC) and analysis of molecular biomarkers of joint cartilage metabolism in body fluids are two such methods that have made it possible to examine cartilage matrix structure and to study metabolic processes in vivo.

From Lund University and the Department of Orthopedics, Malmö University Hospital, Malmö, Sweden.

Address correspondence and reprint requests to Dr. Leif Dahlberg, Dept. of Orthopedics, Malmö University Hospital, SE-205 02 Malmö, Sweden. E-mail:

© 2002 Lippincott Williams & Wilkins, Inc.