Mild Traumatic Brain Injury and Post-concussion Syndrome Treatment and Related Sequela for Persistent Symptomatic DiseaseBramley, Harry DO; Hong, Justin MD; Zacko, Christopher MD; Royer, Christopher Psy.D; Silvis, Matthew MDSports Medicine and Arthroscopy Review: September 2016 - Volume 24 - Issue 3 - p 123–129 doi: 10.1097/JSA.0000000000000111 Review Articles Buy Abstract Author InformationAuthors Article MetricsMetrics Sport-related concussion typically resolves within a few weeks of the injury; however, persistent symptoms have been reported to occur in 10% to 15% of concussions. These ongoing symptoms can cause significant disability and be frustrating for the patient and family. In addition, factors other than brain injury can cause complications for these patients, such as adjustment disorder or exacerbation of preexisting conditions such as depression or migraine. Individuals with prolonged symptoms of concussion may be classified as having post-concussion syndrome. A careful and thoughtful evaluation is important, as the clinician must determine whether these prolonged symptoms reflect brain injury pathophysiology versus another process. Although there have been numerous studies on the acute management of concussion, much less is available on the treatment of persistent disease. This review will provide an evaluation approach for the patient with prolonged concussion symptoms and review recent literature on treatment strategies. Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Hershey, PA Disclosure: The authors declare no conflict of interest. Reprints: Harry Bramley, DO, Department of Pediatrics, Penn State Milton S. Hershey Medical Center, Mail Code H085, 500 University Drive, Hershey, PA 17033 Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.