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00152232-201000002-00024AbstractSpine: Affiliated Society Meeting AbstractsSpine: Affiliated Society Meeting Abstracts© 2010 Lippincott Williams & Wilkins, Inc.
p 64–65Effect of Spinal Shortening on Motor-Evoked Potentials and Spinal Cord Blood Flow† Paper #24Podium Presentation AbstractsModi, Hitesh N. MS, PhD; Suh, Seung-Woo MD, PhD; Yang, Jae Hyuk MD; Hong, Jae-Young MDKorea, Republic ofSummary: Animal study for spinal cord injury using spinal shortening is imperative to be helful.Introduction: Objectives were to study effect of spinal cord injury (SCI) on trans-cranial motor-evoked potential (Tc-MEP) and changes in the spinal cord blood flow (SCBF) on the LASER Doppler.Methods: Experiment was performed in 10 farm-pigs under general anesthesia. Neuromonitoring was done using Tc-MEP, and SCBF was measured using LASER Doppler flow meter. After dissection, pedicle screws were inserted in T10 and T13 level; which was followed by osteotomy and two level (T11-T12) corpectomy. A gradual staged (phase 1:without morphological change, phase 2:cord buckling, and phase 3:cord kinking) spinal shortening was performed, and simultaneously Tc-MEP and SCBF was monitored. After 30 minutes wake-up test was performed and animal was sacrificed and cord biopsy was obtained.Results: During spinal shortening MEP signals were maintained in phasel and phase2; however, during phase 3, all leads were lost suggesting complete SCI (32.2±3.6 mm). The average spinal shortening showing SCI (35±2.7 mm) was similar to average vertebral body height of T11-12 (33.6±1.9 mm) (p=0.115). However, when the distance of spinal shortening was compared with the average segmental height (27.7±1.3 mm) of spinal column (T1-L6), it showed a statistically significant difference (p<0.0001). Considering into percentage of spinal column length, SCI was not occurred at the shortening of 5.1% length of spinal column (safe zone); however, SCI occurred at shortening of 6.3% length of spinal column (unsafe zone). On SCBF measurement, during phase 3 of shortening where it produced SCI, SCBF decreased by 43.1 ± 11.4% (p<0.0001). On wake-up test, we could not observe movements. Histopathology exhibited axonal cutting with ischemic and necrotic changes.Conclusion: Spinal shortening at TL level can be done safely with the shortening of average segmental height or 5.1% length of spinal column (T1-L6); however, it creates SCI if shortening is of average vertebral body height at T11-T12 or 6.3% length of spinal column.Significance: Spinal shortening induced SCI model in pig will highlight its relation with spinal shortening amount in future.<strong xmlns:mrws="http://webservices.ovid.com/mrws/1.0">Effect of Spinal Shortening on Motor-Evoked Potentials and Spinal Cord Blood Flow</strong>: <strong xmlns:mrws="http://webservices.ovid.com/mrws/1.0">† Paper #24</strong>Modi Hitesh N. MS PhD; Suh, Seung-Woo MD, PhD; Yang, Jae Hyuk MD; Hong, Jae-Young MDPodium Presentation AbstractsPodium Presentation Abstractsp 64-65
