INTRODUCTION: Low back pain (LBP) is a health problem with profound impact on individuals, business and society. Understanding of behavior‐related factors for LBP could be of value for clinicians and policy makers as they are potentially modifiable. The goal of this study was to explore behavior‐related factors for LBP in the US adult population, including leisure‐time physical activity, sleep deprivation, tobacco use and obesity. METHOD: The data for this study came from the 2009 to 2012 National Health Interview Survey (NHIS) which is a general health survey conducted in the US. LBP in NHIS was defined as non‐specific Low back pain within the past three months. In order to account for the complex sampling design of the NHIS, the Taylor linearized variance estimation method in STATA 12 was used. Risk of LBP was estimated using multivariable logistic regression. The analysis included 122, 345 adults, aged 18 to 85. RESULTS: Compared with those who were inactive, those who engaged in regular physical at leisure‐time (OR 0.83, CI 0.80, 0.86) were less likely to have LBP. Compared with the life‐time non‐smokers, current regular smokers (OR 1.72, CI 1.63, 1.80) and former smokers (OR 1.35, CI 1.29, 1.40) were more likely to have LBP. Compared with those who had 7‐8 hours of sleep, those who slept 3‐4 hours (OR 2.85, CI 2.58, 3.15) and those who slept 5‐6 hours per 24 hours (OR 1.50, CI 1.45, 1.56) were more likely to have LBP. Those who were obese (OR 1.44, CI 1.38, 1.50) and those who were overweight (OR 1.14, CI 1.10, 1.19) had a limited increased risk for LBP. DISCUSSION: This study identified a number of behavioral factors associated with LBP in the adult population of the US. Although it is still unclear that they were risk factors, comorbidities or prognostic factors for LBP, the findings of this study have important policy and clinical implications in reducing LBP prevalence and counseling LBP patients. This study also supports future longitudinal research.