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00152232-201500001-00027ArticleSpine: Affiliated Society Meeting AbstractsSpine: Affiliated Society Meeting Abstracts© 2015 Lippincott Williams & Wilkins, Inc.2015 p 27LONG-TERM OUTCOME OF SURGERY FOR LUMBAR DEGENERATIVE SPONDYLOLISTHESIS IN A PROSPECTIVE RANDOMIZED CLINICAL TRIALO80ArticleKato, Tsuyoshi; Yoshii, Toshitaka; Inose, Hiroyuki; Hirai, Takashi; Yamada, Tsuyoshi; Sakai, Kenichiro; Arai, Yoshiyasu; Okawa, AtsushiTokyo Medical and Dental University, Dept. of Orthopaedic SurgeryINTRODUCTION: To investigate the necessity and efficacy of stabilization or fixation after posterior decompression for lumbar degenerative spondylolisthesis (LDS), we have been conducting a multicenter prospective randomized clinical trial (RCT) approved by the IRB of our hospital. We have previously reported short-term outcome; here, we report long-term (≥5 years) surgical outcome. METHODS: Subjects were patients indicated for decompression for central canal stenosis or lateral recess stenosis at the L4/5 due to LDS. After providing informed consent, patients were divided into three groups: decompression only (D group); decompression + Graf stabilization (G group); and decompression + posterolateral fusion (P group). A prospective comparative study of JOA scores, VAS, SF36 results, and Xp and CT findings was performed at pre- and postoperative years 2 and 5, and at final. RESULTS: We followed 45 patients of those 15, 14, and 16 patients were in the D, G, and P groups, respectively. Mean observation period was 79.0, 80.4, and 80.7 months, respectively (overall about 7 years). Preoperative (final) JOA scores were respectively D:14.7 (24.1), G:16.5 (25.3), and P:17.3 (25.2). Re-operation was performed in only 1 patient (D group) who had foraminal stenosis. In the D group, we found a trend a gradual worse in JOA and VAS scores related to low back pain, as well as fusion at the intervertebral joint on CT images in 12 patients (80%). A gradual narrowing of the disc space at L3/4 was observed in all groups, and L4/5 spinal fusion was also prevalent in the G group. At the final follow-up, stabilization of the intervertebral joint was observed in all groups. DISCUSSION: In this RCT evaluating surgical procedures for LDS, no significant difference by group was observed in surgical outcome or imaging findings at ≥7 years after surgery as well as at 2 years, suggesting the efficacy of fenestration alone. We plan to elucidate preoperative prognostic factors.<strong xmlns:mrws="http://webservices.ovid.com/mrws/1.0">LONG-TERM OUTCOME OF SURGERY FOR LUMBAR DEGENERATIVE SPONDYLOLISTHESIS IN A PROSPECTIVE RANDOMIZED CLINICAL TRIAL</strong>: <strong xmlns:mrws="http://webservices.ovid.com/mrws/1.0">O80</strong>Kato Tsuyoshi; Yoshii, Toshitaka; Inose, Hiroyuki; Hirai, Takashi; Yamada, Tsuyoshi; Sakai, Kenichiro; Arai, Yoshiyasu; Okawa, AtsushiArticleArticle2015p 27