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00152232-201500001-00029ArticleSpine: Affiliated Society Meeting AbstractsSpine: Affiliated Society Meeting Abstracts© 2015 Lippincott Williams & Wilkins, Inc.2015 p 29BONE UNION RATE OF PLIF USING LOCAL BONE GRAFT IN LONG TERM BISPHOSPHONATES USERSO47ArticlePark, Si Young; Suh, Seung Woo; Hong, Jae Young; Yang, Jae Hyuck; Lee, Hyun MinDepartment of Orthopaedic Surgery, Korea University College of MedicineINTRODUCTION: Bisphosphonates are the most popular drugs for treatment of postmenopausal osteoporosis. However, long-term use of bisphosphonates (BPs) may cause several complications such as atypical fracture of hip, osteonecrosis of jaw and delayed fracture healing. PLIF is a typical surgical technique for treatment of degenerative spinal disorders. Long-term use of BPs may also inhibit spinal fusion process after PLIF. We compared bony union rates of long-term BPs users and non-users after undergoing PLIF. METHODS: The subject were 95 postmenopausal women whose course could be observed for at least 2 years after surgery. Single interbody PLIF was done using local bone graft from laminectomy. Participants were divided into two groups; there were 62 patients in long-term BPs users group and 33 in non-users group. Serum C-terminal cross linking telopeptide levels were checked for bone resorption marker which could be extremely decreased in long-term BPs users. Bone fusion rates were calculated, 2 years after the surgery using plain radiographs and computed tomographic scans. Clinical outcomes were measured using ODI and VAS. RESULTS: Serum CTX level was extremely decreased in long-term BPs user group (p<0.05). However, fusion rates turned out to be 82% in long-term BPs users group and 87% in non-users group (p>0.05, not significant). There was no significant difference between two groups in ODI and VAS. DISCUSSION: At the two-year postoperative follow-up, there was no significant difference in bone fusion rate between two groups. Long-term BPs users showed fusion rates greater than 80% and clinical outcome improvement that were compatible to those in non-users. No significant effect was found after long-term BPs use on fusion rate of PLIF.<strong xmlns:mrws="http://webservices.ovid.com/mrws/1.0">BONE UNION RATE OF PLIF USING LOCAL BONE GRAFT IN LONG TERM BISPHOSPHONATES USERS</strong>: <strong xmlns:mrws="http://webservices.ovid.com/mrws/1.0">O47</strong>Park Si Young; Suh, Seung Woo; Hong, Jae Young; Yang, Jae Hyuck; Lee, Hyun MinArticleArticle2015p 29