Secondary Logo

Journal Logo

Vertebral Growth Modulation in the Porcine Scoliosis Model Assessed by Computed Tomography: 3‐D Effect of a Corrective Tether: †Paper #26

Schwab, Frank J. MD; Patel, Ashish MD; Lafage, Virginie C. PhD; Ungar, Benjamin; Farcy, Jean‐Pierre C. MD

Author Information
Spine Journal Meeting Abstracts: 2010 - Volume - Issue - p 65–66
  • Free

Summary: Using an established porcine scoliosis model, this study aimed to investigate the 3D effect of an anterior corrective tether (non‐fusion technology). Thin CT scan reconstructions were obtained and analyzed to compare the corrective group (n=5) to a control group (n=5). This study demonstrated that using an anterior tether, favorable growth modulation was possible without affecting the overall vertebral volume and lead to a 3 plane correction of the scoliosis: correction of coronal cobb, reduction of axial rotation, restoration of sagittal kyphosis

Introduction: In theory, vertebral growth modulation through a convexly placed tethering implant in the setting of scoliosis would lead to progressive vertebral correction in the coronal plane (Hueter‐Volkmann Principle). Using an established Porcine Scoliosis Model, this study aims to investigate the impact of a non‐fusion corrective anterior convex spinal tether on an induced deformity, examining detailed vertebral morphology and axial rotation.

Methods: This IACUC approved Study included 10 immature Yorkshire Pigs divided into 2 groups; tether release group (TR, n=5) and corrective tether group (CR, n=5). All animals underwent induction of scoliosis. Once >50° was noted on radiographic follow up a second surgical intervention was pursued: TR had release of the inducing tether; AC had tether release and placement of a corrective tether over the 5 apical vertebrae. Both groups were observed for 20 weeks then euthanized. Fine cut CT scans were used to create a volumetric 3D reconstruction of the apex (3vertebrae, 2discs). Student T‐test was used to evaluate differences between groups.

Figure. No capation ...
Figure. No capation ...:
Figure. No capation available.

Results: Regarding absolute vertebral heights, no significant differences were observed between TR and AC in posterior and concave dimensions. However, significant reduction was found in anterior and convex AC vertebral heights; TR 8.9cm vs. AC 7.9cm (p<0.01) and TR 9.8cm vs. AC 8.7cm (p<0.01) respectively. No significant difference was found in apical vertebral body volumes between TR 18.3cm3 and AC 17.7cm3 while the AC group presented bigger vertebral enplates:TR=5cm2, AC=5.5cm2 (p=0.01) A significant reduction in coronal wedging angle of 18° was found between TR=36.1° and AC=18.1° (p<0.01). A significant increase in sagittal kyphosis was observed over the apex: TR= +6° AC= ‐9.6° (p=0.04). A 25% correction in apical rotation was demonstrated in the transverse plane

Conclusion: This study demonstrated that using an anterior tether, favorable growth modulation was possible without affecting the overall vertebral volume and lead to a 3 plane correction of the scoliosis: correction of coronal cobb, reduction of axial rotation, restoration of sagittal kyphosis

© 2010 Lippincott Williams & Wilkins, Inc.