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Risk Factors for Major Peri‐Operative Complications in Adult Spinal Deformity Surgery: A Multi‐Center Review of 953 Consecutive Patients: *Paper #33

Schwab, Frank J. MD; Hawkinson, Nicola MA, NP; Lafage, Virginie C. PhD; Hart, Robert A. MD; Mundis, Gregory M. MD; Burton, Douglas C. MD; Line, Breton BSME; Akbarnia, Behrooz A. MD; Boachie‐Adjei, Oheneba MD; Hostin, Richard MD; Shaffrey, Christopher I. MD; Smith, Justin S. MD, PhD; Wood, Kirkham B. MD; Bess, Shay MD

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Spine Journal Meeting Abstracts: 2010 - Volume - Issue - p 70–71
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Summary: Peri‐operative major complications following adult spinal deformity surgery remain common. However, risk factors in terms of patient profile and surgical parameters have not been clearly identified. Using a retrospective consecutive review of 953 patients with at least 2y FU, we identified 72 patients who suffered a major peri‐operative complication. Comparison to a case control group demonstrated that a major complication was more likely to occur with revision, staged, and anterior/posterior surgeries.

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Introduction: Complications following adult spinal deformity (ASD) surgery have a reported incidence of 27%‐80%. Understanding risk factors for complications may reduce their occurrence and permit improved operative risk‐benefit ratios. The purpose was to identify patient and surgical parameters that correlate with development of major peri‐operative complications following ASD surgery.

Methods: Multi‐center (n=8), retrospective, consecutive, case‐control series. A total of 953 patients (2y FU minimum) with ASD were reviewed to identify patients with major peri‐operative complications (Case). A randomization table was used to select a control group of patients that did not suffer major complications (Control). Data collected included demographics, past medical history, ASA grade, co‐morbidities, preoperative lab values, intra/post‐operative parameters, occurrence of peri‐operative complication. The two groups were analyzed for differences using ANOVA and Chi Square analysis.

Results: We observed 99 major complications (average 1.4 per patient) in 72 patients (7.6%). The matched cohort consisted of 78. No differences were noted between groups for the following: demographics, pre‐op vitals, lab‐results, ASA grade, respiratory signs, alcohol or smoking habits, mean operative time, and ICU stay. Chi‐square analysis demonstrated that the complication group exhibited a higher percentage of staging procedures (46% versus 37%, p=0.011), a higher percentage of anterior/posterior approach (56% versus 32%, p=0.011; Figure) and a greater prevalence of postoperative anemia (16.7% versus 6.4%, p=0.04).

Conclusion: We report an incidence of 7.6% major complications among 953 consecutive patients. Improved understanding of risk profiles and procedure‐related parameters may assist in pre‐operative risk‐benefit surgical discussions and pre‐emptive approaches to reduce major complications. Patients should be counseled that a major complication is more likely to occur in the setting of revision, staged, and anterior/posterior surgery.

© 2010 Lippincott Williams & Wilkins, Inc.