In Brief:
In this study, human mesenchymal stromal cells and osteoblasts were treated with riluzole of different concentrations for 1, 2, 3, and 4 weeks. We found no cytotoxicity or increased proliferation in primary human mesenchymal stromal cells and human osteoblasts cultured with riluzole over 7 days. Alkaline phosphatase activity was increased in human mesenchymal stromal cells and human osteoblasts after treatment with riluzole.