In Brief:
The key components of the Src/Stat3 signaling cascade was expressed in chordomas. Two-cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic acid-methyl ester is able to block the Src/Stat3 pathway, induce apoptosis, and inhibit the growth of chordoma cells at the same time. Two-cyano-3,12-dioxooleana-1,9 (11)-dien-28-oic acid-methyl ester seems to have a synergistic effect on cisplatin or doxorubicin-induced chordoma cell death.