The Lone Cypress, Monterey, California Thomas, Valorie Thomas, Valorie Less Spine. 33(8):i, April 15, 2008. Favorites PDF Get Content & Permissions Free
Cell Therapy Using Articular Chondrocytes Overexpressing BMP-7 or BMP-10 in a Rabbit Disc Organ Culture Model Zhang, Yejia; Phillips, Frank M.; Thonar, Eugene J.-M.A.; More Zhang, Yejia; Phillips, Frank M.; Thonar, Eugene J.-M.A.; Oegema, Theodore; An, Howard S.; Roman-Blas, Jorge A.; He, Tong-Chuan; Anderson, D Greg Less Spine. 33(8):831-838, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Back pain associated with intervertebral disc degeneration is a common clinical condition. Growth factors stimulate disc cell metabolism; however, the ideal delivery method has not been established. Our study demonstrates that articular chondrocytes overexpressing human BMP-7 promote disc proteoglycan accumulation and suggests that this approach may present a valid treatment option. Buy
Plasmin-Matrix Metalloproteinase Cascades in Spinal Response to an Experimental Disc Lesion in Pig Salo, Jari; Mackiewicz, Zygmunt; Indahl, Aage; More Salo, Jari; Mackiewicz, Zygmunt; Indahl, Aage; Konttinen, Yrjö T.; Holm, Allison Kaigle; Sukura, Antti; Holm, Sten Less Spine. 33(8):839-844, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Immunohistochemical analysis of VEGF receptors was performed in experimental trauma-induced intervertebral disc degeneration in pigs. Angiogenesis and adaptive/reactive vertebral bone remodeling were found to accompany disc degeneration. VEGF receptors were expressed to different extent in different tissues undergoing degradation and/or reparation. Buy
Age-Related Effects of Cocultured Rat Nucleus Pulposus Cells and Macrophages on Nitric Oxide Production and Cytokine Imbalance Katsuno, Raijiro; Hasegawa, Toru; Iwashina, Toru; More Katsuno, Raijiro; Hasegawa, Toru; Iwashina, Toru; Sakai, Daisuke; Mikawa, Yoshihiro; Mochida, Joji Less Spine. 33(8):845-849, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The age-related effects on nitric oxide (NO) and cytokine production were studied in an in vitro model of cocultured rat nucleus pulposus (NP) cells and macrophages. The NO levels of coculture increased with age. Younger rat NP cells had higher cell-mediated immunity activity, while the older rat NP cells had higher humoral immunity activity, demonstrating an age-related cytokine imbalance. Buy
Puncture of a Lumbar Intervertebral Disc Induces Changes in Spontaneous Pain Behavior: An Experimental Study in Rats Olmarker, Kjell Olmarker, Kjell Less Spine. 33(8):850-855, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Puncture of a lumbar intervertebral disc in the rat produces changes in spontaneous behavior mainly seen as increased “grooming” and “wet-dog shakes,” 2 behaviors that have been suggested to indicate stress and pain. Buy
An Intact Facet Capsular Ligament Modulates Behavioral Sensitivity and Spinal Glial Activation Produced by Cervical Facet Joint Tension Winkelstein, Beth A.; Santos, Diana G. Winkelstein, Beth A.; Santos, Diana G. Less Spine. 33(8):856-862, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Cervical facet joint loading that produces pain requires the capsular ligament be intact for mechanical allodynia to be produced. Allodynia was not produced for joint distraction across a transected facet capsule. Spinal astrocytic activation is also modulated in this model by an intact capsular ligament and relates to mechanical allodynia. Buy
Comparison of Human Mesenchymal Stem Cells Derived From Adipose Tissue and Bone Marrow for Ex Vivo Gene Therapy in Rat Spinal Fusion Model Miyazaki, Masashi; Zuk, Patricia A.; Zou, Jun; More Miyazaki, Masashi; Zuk, Patricia A.; Zou, Jun; Yoon, Seung Hwan; Wei, Feng; Morishita, Yuichiro; Sintuu, Chananit; Wang, Jeffrey C. Less Spine. 33(8):863-869, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The present study demonstrated that human adipose tissue-derived mesenchymal stem cells transfected with BMP-2-containing adenovirus induce abundant posterolateral spinal fusion at 8 weeks in an athymic rat model as efficiently as similarly genetically modified human bone marrow-derived mesenchymal stem cells. Buy SDC
Coculture of Bone Marrow Mesenchymal Stem Cells and Nucleus Pulposus Cells Modulate Gene Expression Profile Without Cell Fusion Vadalà, Gianluca; Studer, Rebecca K.; Sowa, Gwendolyn; More Vadalà, Gianluca; Studer, Rebecca K.; Sowa, Gwendolyn; Spiezia, Filippo; Iucu, Cristina; Denaro, Vincenzo; Gilbertson, Lars G.; Kang, James D. Less Spine. 33(8):870-876, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Mesenchymal stem cell (MSC) and nucleus pulposus cell (NPC) interaction after coculture induces a change in MSCs towards a more chondrogenic gene expression profile without cell fusion. This study clarifies the mechanisms of MSC and NPC interaction in a 3-dimensional environment, supporting the use of undifferentiated MSC for treatment of disc degeneration. Buy
Early Histologic Changes Following Polymethylmethacrylate Injection (Vertebroplasty) in Rabbit Lumbar Vertebrae Urrutia, Julio; Bono, Christopher M.; Mery, Pablo; More Urrutia, Julio; Bono, Christopher M.; Mery, Pablo; Rojas, Claudio Less Spine. 33(8):877-882, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Early histologic effects of polymethylmethacrylate injection on bone and intraosseous neural tissue were studied in lumbar rabbit vertebrae. Only half of the levels studied showed necrosis at the bone-cement interface, most with focal necrosis only; no controls displayed bone necrosis. No intraosseous neural tissue necrosis was observed. Buy
A Biomechanical Study of Artificial Cervical Discs Using Computer Simulation Ahn, Hyung Soo; DiAngelo, Denis J. Ahn, Hyung Soo; DiAngelo, Denis J. Less Spine. 33(8):883-892, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A computer simulation model of the subaxial cervical spine was used to study 3 different prosthetic disc designs. The simulation model showed the impact simple design changes may have on cervical disc dynamics. Buy
Biomechanics of Volunteers Subject to Loading by a Motorized Shoulder Belt Tensioner Good, Craig A.; Viano, David C.; Ronsky, Janet L. Good, Craig A.; Viano, David C.; Ronsky, Janet L. Less Spine. 33(8):E225-E235, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Pre-crash shoulder belt tensioning is a new technology that may reduce automotive crash injuries. Experiments were performed with 3 sizes of human volunteers leaning forward to quantify the biomechanics of the upper torso during seatbelt tensioning. Buy
How Does a Three-Dimensional Continuum Muscle Model Affect the Kinematics and Muscle Strains of a Finite Element Neck Model Compared to a Discrete Muscle Model in Rear-End, Frontal, and Lateral Impacts Hedenstierna, Sofia; Halldin, Peter Hedenstierna, Sofia; Halldin, Peter Less Spine. 33(8):E236-E245, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A comparative study of a finite element neck model with incorporated musculature in the form of continuum or discrete elements respectively during impact analysis of volunteer experiments was performed. The continuum model predicted a stiffer response than the discrete model, especially in rear impact. Buy
Quantitative Anatomy of Subaxial Cervical Lateral Mass: An Analysis of Safe Screw Lengths for Roy-Camille and Magerl Techniques Stemper, Brian D.; Marawar, Satyajit V.; Yoganandan, Narayan; More Stemper, Brian D.; Marawar, Satyajit V.; Yoganandan, Narayan; Shender, Barry S.; Rao, Raj D. Less Spine. 33(8):893-897, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Inappropriate screw length selection during lateral mass screw insertion can result in neurovascular injury or facet joint damage. Mean lateral mass screw lengths with Roy-Camille and Magerl techniques of screw insertion were determined at all subaxial cervical levels using computed tomography scans of an asymptomatic, young North American population. Buy
Facet Asymmetry in Normal Vertebral Growth: Characterization and Etiologic Theory of Scoliosis Masharawi, Youssef M.; Peleg, Smadar; Albert, Hanne B.; More Masharawi, Youssef M.; Peleg, Smadar; Albert, Hanne B.; Dar, Gali; Steingberg, Nili; Medlej, Bahaa; Abbas, Janan; Salame, Khalil; Mirovski, Yigal; Peled, Nathan; Hershkovitz, Israel Less Spine. 33(8):898-902, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Shape and orientation of the zygapophyseal facets of all thoracic and lumbar defleshed vertebrae were measured in 32 children. A pattern of shorter, wider, and more frontally oriented right thoracic facets is indicated in children. Buy
Clinical Course and Significance of the Clear Zone Around the Pedicle Screws in the Lumbar Degenerative Disease Tokuhashi, Yasuaki; Matsuzaki, Hiromi; Oda, Hiroshi; More Tokuhashi, Yasuaki; Matsuzaki, Hiromi; Oda, Hiroshi; Uei, Hiroshi Less Spine. 33(8):903-908, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: The clinical course and significance of postoperative radiolucent zones (so-called “clear zones”) around pedicle screw fixation were evaluated in 190 patients. Although approximately two thirds of the clear zones disappeared over time, they were observed in 93.3% of patients with pseudoarthrosis. The continued presence of clear zones around pedicle screws suggests the presence of pseudoarthrosis. Buy
Threshold Cervical Range-of-Motion Necessary to Detect Abnormal Intervertebral Motion in Cervical Spine Radiographs Hwang, HoSun; Hipp, John A.; Ben-Galim, Peleg; More Hwang, HoSun; Hipp, John A.; Ben-Galim, Peleg; Reitman, Charles A. Less Spine. 33(8):E261-E267, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A whole cadaver model was used to determine how much gross sagittal plane flexion/extension rotation of the head/neck is required to detect damage to the soft tissues between vertebrae. The results suggest that at least 60° of flexion/extension of the head is required. The center-of-rotation was the most sensitive parameter. Buy
Pain in the Back and Neck Are With Us Until the End: A Nationwide Interview-Based Survey of Danish 100-Year-Olds Hartvigsen, Jan; Christensen, Kaare Hartvigsen, Jan; Christensen, Kaare Less Spine. 33(8):909-913, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Studying disease over the entire human lifespan can help us understand underlying causes and mechanisms. As part of an interview-based nationwide survey on general health among centenarians, we therefore included questions about back and neck pain and their impact in this age group. Buy
The Use of Expertise-Based Randomized Controlled Trials to Assess Spinal Manipulation and Acupuncture for Low Back Pain: A Systematic Review Johnston, Bradley C.; da Costa, Bruno R.; Devereaux, P J.; More Johnston, Bradley C.; da Costa, Bruno R.; Devereaux, P J.; Akl, Elie A.; Busse, Jason W.; on behalf of the Expertise-Based RCT Working Group Less Spine. 33(8):914-918, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Expertise-based randomization may decrease bias in nonpharmacological RCTs. We conducted a systematic review of RCTs exploring the efficacy of acupuncture or spinal manipulation for low back pain to investigate the use of expertise-based design. Twelve RCTs were identified that compared competing therapist-administered therapies; none made use of expertise-based randomization. Buy SDC
Vertebroplasty Using Real-Time, Fluoroscopy-Controlled, Catheter-Assisted, Low-Viscosity Cement Injection Lee, Chung-Wei; Wang, Yao-Hung; Liu, Hon-Man; More Lee, Chung-Wei; Wang, Yao-Hung; Liu, Hon-Man; Chen, Ya-Fang; Hsieh, Hung-Jen Less Spine. 33(8):919-924, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: We described a new vertebroplasty technique by using real-time, fluoroscopy-controlled, catheter-assisted, low-viscosity cement injection. The results are comparable to previously reported results using high-viscosity cements. Buy
Historical Perspective: The Development and Use of Spinal Disease Categories Weiner, Bradley K. Weiner, Bradley K. Less Spine. 33(8):925-930, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: This historical perspective traces the history of the development of pathoanatomically based spinal disease diagnosis and the subsequent use of these diagnoses for scientific and social purposes. Buy
Long-term Functional Outcome in Pyogenic Spinal Infection O'Daly, Brendan J.; Morris, Seamus F.; O'Rourke, S Kieran O'Daly, Brendan J.; Morris, Seamus F.; O'Rourke, S Kieran Less Spine. 33(8):E246-E253, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Poor functional outcome in pyogenic spinal infection at long-term follow-up is reported using Oswestry disability index and short form-36 health survey as standardized outcome measures. Even with apparent full neurologic recovery, SF-36 scores fail to reach those of an age-matched normative population. Buy
Diabetes and Perioperative Outcomes Following Cervical Fusion in Patients With Myelopathy Cook, Chad; Tackett, Sean; Shah, Anand; More Cook, Chad; Tackett, Sean; Shah, Anand; Pietrobon, Ricardo; Browne, James; Viens, Nicholas; Richardson, William; Isaacs, Robert Less Spine. 33(8):E254-E260, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: This study examined the effect of diabetes (and subclassifications of Type I/Type II and control/uncontrolled) on perioperative complications and discharge outcomes in patients who receive cervical fusion secondary to myelopathy. Results indicate that uncontrolled diabetes leads to the greatest number of perioperative complications, nonroutine discharges, and total charges. Buy Erratum
Delayed Migration of a Screw Into the Gastrointestinal Tract After Anterior Cervical Spine Plating Gazzeri, Roberto; Tamorri, Marco; Faiola, Andrea; More Gazzeri, Roberto; Tamorri, Marco; Faiola, Andrea; Gazzeri, Giovanni Less Spine. 33(8):E268-E271, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: A 45-year-old man underwent anterior cervical surgical decompression and fusion with plating. He returned 11 years after surgery and several radiographs of the cervical spine showed a screw back-out and migration of the screw into the gastrointestinal tract. Barium meal swallowing test showed no leakage on the cervical area. Buy
Compartment Syndrome With Acute Renal Failure: A Rare Complication of Spinal Surgery in Knee-Chest Position Gupta, Rajiv; Batra, Sumit; Chandra, Rajesh; More Gupta, Rajiv; Batra, Sumit; Chandra, Rajesh; Sharma, V K. Less Spine. 33(8):E272-E273, April 15, 2008. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions In Brief: Prolonged compression of calf and thigh muscles during surgery in knee-chest position can lead to ischemic necrosis and compartment syndrome (Aschoff, et al. Neurosurg Rev 1990;13:155–9). Leakage of myoglobin from damaged muscles can block the renal tubules causing acute renal failure (Gordon and Newman. J Bone Joint Surg A 1953;35:764–7; Keim and Weinstein. J Bone Joint Surg A 1970;52:1248–50). A case of compartment syndrome with acute renal failure is presented that occurred after discectomy in knee-chest position that lasted for approximately 6 hours. Buy
Online Article Abstracts Less Spine. 33(8):A12-A14, April 15, 2008. Favorites PDF Get Content & Permissions Buy
