Discogenic Origins of Spinal Instability Zhao, Fengdong; Pollintine, Phillip; Hole, Barny D.; More Zhao, Fengdong; Pollintine, Phillip; Hole, Barny D.; Dolan, Patricia; Adams, Michael A. Less Spine. 30(23):2621-2630, December 1st, 2005. Abstract Abstract In Brief In Brief Favorites PDF Get Content & Permissions Abstract: In Brief: Physical effects of disc degeneration were simulated on cadaveric thoracolumbar motion segments by creep-induced water loss and endplate disruption. Both interventions markedly increased spinal “instability” as indicated by neutral zone, range of motion, bending stiffness, and translational movements. Endplate disruption contributed more to instability than did disc dehydration.