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Articles by Howard S. An, MD

In Vivo 3-Dimensional Morphometric Analysis of the Lumbar Foramen in Healthy Subjects

Senoo, Issei; Espinoza Orías, Alejandro A.; An, Howard S.; More

Spine. 39(16):E929-E935, July 15, 2014.

Fibronectin Fragments and the Cleaving Enzyme ADAM-8 in the Degenerative Human Intervertebral Disc

Ruel, Nancy; Markova, Dessislava Z.; Adams, Sherrill L.; More

Spine. 39(16):1274-1279, July 15, 2014.

Histological Features of Endplates of the Mammalian Spine: From Mice to Men

Zhang, Yejia; Lenart, Brett A.; Lee, Joseph K.; More

Spine. 39(5):E312-E317, March 01, 2014.

In Vivo Topographic Analysis of Lumbar Facet Joint Space Width Distribution in Healthy and Symptomatic Subjects

Simon, Peter; Orías, Alejandro A. Espinoza; Andersson, Gunnar B. J.; More

Spine. 37(12):1058-1064, May 20, 2012.

Biomechanical Comparison of Occiput-C1–C2 Fixation Techniques: C0–C1 Transarticular Screw and Direct Occiput Condyle Screw

Takigawa, Tomoyuki; Simon, Peter; Orías, Alejandro A. Espinoza; More

Spine. 37(12):E696-E701, May 20, 2012.

Histological Features of the Degenerating Intervertebral Disc in a Goat Disc-Injury Model

Zhang, Yejia; Drapeau, Susan; An, Howard S.; More

Spine. 36(19):1519-1527, September 01, 2011.

Biomechanical Comparison of Three Different Types of C7 Fixation Techniques

Hong, Jae Taek; Tomoyuki, Takigawa; Udayakumar, Ranjith; More

Spine. 36(5):393-398, March 1, 2011.

Simulation of Inhomogeneous Rather Than Homogeneous Poroelastic Tissue Material Properties Within Disc Annulus and Nucleus Better Predicts Cervical Spine Response: A C3–T1 Finite Element Model Analysis Under Compression and Moment Loadings

Hussain, Mozammil; Natarajan, Raghu N.; Chaudhary, Gulafsha; More

Spine. 36(4):E245-E255, February 15, 2011.

Motion Changes in Adjacent Segments due to Moderate and Severe Degeneration in C5–C6 Disc: A Poroelastic C3–T1 Finite Element Model Study

Hussain, Mozammil; Natarajan, Raghu N.; An, Howard S.; More

Spine. 35(9):939-947, April 20, 2010.

In Vivo Measurement of Lumbar Facet Joint Area in Asymptomatic and Chronic Low Back Pain Subjects

Otsuka, Yoshihisa; An, Howard S.; Ochia, Ruth S.; More

Spine. 35(8):924-928, April 15, 2010.

Does Multilevel Lumbar Stenosis Lead to Poorer Outcomes?: A Subanalysis of the Spine Patient Outcomes Research Trial (SPORT) Lumbar Stenosis Study

Park, Daniel K.; An, Howard S.; Lurie, Jon D.; More

Spine. 35(4):439-446, February 15, 2010.

In Vivo Three-Dimensional Morphometric Analysis of the Lumbar Pedicle Isthmus

Sugisaki, Keizo; An, Howard S.; Espinoza Orías, Alejandro A.; More

Spine. 34(24):2599-2604, November 15, 2009.

En Bloc Spondylectomy for the Treatment of Spinal Tuberculosis With Fixed and Sharply Angulated Kyphotic Deformity

Deng, Youwen; Lv, Guohua; An, Howard S.

Spine. 34(20):2140-2146, September 15, 2009.

Age-Related Changes in the Extracellular Matrix of Nucleus Pulposus and Anulus Fibrosus of Human Intervertebral Disc

Singh, Kern; Masuda, Koichi; Thonar, Eugene J-M. A.; More

Spine. 34(1):10-16, January 1, 2009.

The Action of Resveratrol, a Phytoestrogen Found in Grapes, on the Intervertebral Disc

Li, Xin; Phillips, Frank M.; An, Howard S.; More

Spine. 33(24):2586-2595, November 15, 2008.

Anatomical Variations of the Vertebral Artery Segment in the Lower Cervical Spine: Analysis by Three-Dimensional Computed Tomography Angiography

Hong, Jae Taek; Park, Daniel K.; Lee, Michael J.; More

Spine. 33(22):2422-2426, October 15, 2008.

Cell Therapy Using Articular Chondrocytes Overexpressing BMP-7 or BMP-10 in a Rabbit Disc Organ Culture Model

Zhang, Yejia; Phillips, Frank M.; Thonar, Eugene J.-M.A.; More

Spine. 33(8):831-838, April 15, 2008.

Comparative Effects of Bone Morphogenetic Proteins and Sox9 Overexpression on Matrix Accumulation by Bovine Anulus Fibrosus Cells: Implications for Anular Repair

Zhang, Yejia; Anderson, D Greg; Phillips, Frank M.; More

Spine. 32(23):2515-2520, November 1, 2007.

Aggrecanases and Aggrecanase-generated Fragments in the Human Intervertebral Disc at Early and Advanced Stages of Disc Degeneration

Patel, Kalpa P.; Sandy, John D.; Akeda, Koji; More

Spine. 32(23):2596-2603, November 1, 2007.

The Apoptotic Effects of Oxidative Stress and Antiapoptotic Effects of Caspase Inhibitors on Rat Notochordal Cells

Kim, Ki-Won; Ha, Kee-Yong; Lee, Jun-Seok; More

Spine. 32(22):2443-2448, October 15, 2007.

In Vivo Measurements of Lumbar Segmental Motion During Axial Rotation in Asymptomatic and Chronic Low Back Pain Male Subjects

Ochia, Ruth S.; Inoue, Nozomu; Takatori, Ryota; More

Spine. 32(13):1394-1399, June 1, 2007.

Recombinant Human Osteogenic Protein-1 Upregulates Proteoglycan Metabolism of Human Anulus Fibrosus and Nucleus Pulposus Cells

Imai, Yoshiyuki; Miyamoto, Kei; An, Howard S.; More

Spine. 32(12):1303-1309, May 20, 2007.

Restoration of Disc Height Loss by Recombinant Human Osteogenic Protein-1 Injection Into Intervertebral Discs Undergoing Degeneration Induced by an Intradiscal Injection of Chondroitinase ABC

Imai, Yoshiyuki; Okuma, Masahiko; An, Howard S.; More

Spine. 32(11):1197-1205, May 15, 2007.

Axonal Growth Potential of Lumbar Dorsal Root Ganglion Neurons in an Organ Culture System: Response of Nerve Growth Factor-sensitive Neurons to Neuronal Injury and an Inflammatory Cytokine

Aoki, Yasuchika; An, Howard S.; Takahashi, Kazuhisa; More

Spine. 32(8):857-863, April 15, 2007.

Proinflammatory Cytokines Stimulate the Expression of Nerve Growth Factor by Human Intervertebral Disc Cells

Abe, Yumiko; Akeda, Koji; An, Howard S.; More

Spine. 32(6):635-642, March 15, 2007.

The Expression of NG2 Proteoglycan in the Human Intervertebral Disc

Akeda, Koji; An, Howard S.; Pichika, Rajeswari; More

Spine. 32(3):306-314, February 1, 2007.

Effects of Growth Differentiation Factor-5 on the Intervertebral Disc−In Vitro Bovine Study and In Vivo Rabbit Disc Degeneration Model Study

Chujo, Takehide; An, Howard S.; Akeda, Koji; More

Spine. 31(25):2909-2917, December 1, 2006.

Comparative Effects of Bone Morphogenetic Proteins and Sox9 Overexpression on Extracellular Matrix Metabolism of Bovine Nucleus Pulposus Cells

Zhang, Yejia; An, Howard S.; Thonar, Eugene J.-M.A.; More

Spine. 31(19):2173-2179, September 1, 2006.

Three-Dimensional In Vivo Measurement of Lumbar Spine Segmental Motion

Ochia, Ruth S.; Inoue, Nozomu; Renner, Susan M.; More

Spine. 31(18):2073-2078, August 15, 2006.

Platelet-Rich Plasma (PRP) Stimulates the Extracellular Matrix Metabolism of Porcine Nucleus Pulposus and Anulus Fibrosus Cells Cultured in Alginate Beads

Akeda, Koji; An, Howard S.; Pichika, Rajeswari; More

Spine. 31(9):959-966, April 20, 2006.

Osteogenic Protein-1 Injection Into a Degenerated Disc Induces the Restoration of Disc Height and Structural Changes in the Rabbit Anular Puncture Model

Masuda, Koichi; Imai, Yoshiyuki; Okuma, Masahiko; More

Spine. 31(7):742-754, April 1, 2006.

Anti-Adhesion Properties of a Thrombin-Based Hemostatic Gelatin in a Canine Laminectomy Model: A Biomechanical, Biochemical, and Histologic Study

Miyamoto, Kei; Masuda, Koichi; Inoue, Nozomu; More

Spine. 31(4):E91-E97, February 15, 2006.

Transduced Bovine Articular Chondrocytes Affect the Metabolism of Cocultured Nucleus Pulposus Cells In Vitro: Implications for Chondrocyte Transplantation Into the Intervertebral Disc

Zhang, Yejia; Li, Zhen; Thonar, Eugene J.-M. A.; More

Spine. 30(23):2601-2607, December 1, 2005.

Exposure to Pulsed Low Intensity Ultrasound Stimulates Extracellular Matrix Metabolism of Bovine Intervertebral Disc Cells Cultured in Alginate Beads

Miyamoto, Kei; An, Howard S.; Sah, Robert L.; More

Spine. 30(21):2398-2405, November 1, 2005.

A Prospective Cohort Analysis of Adjacent Vertebral Body Bone Mineral Density in Lumbar Surgery Patients With or Without Instrumented Posterolateral Fusion: A 9- to 12-Year Follow-Up

Singh, Kern; An, Howard S.; Samartzis, Dino; More

Spine. 30(15):1750-1755, August 1, 2005.

Is Autograft the Gold Standard in Achieving Radiographic Fusion in One-Level Anterior Cervical Discectomy and Fusion With Rigid Anterior Plate Fixation?

Samartzis, Dino; Shen, Francis H.; Goldberg, Edward J.; More

Spine. 30(15):1756-1761, August 1, 2005.

Expressions of Membrane-Type I Matrix Metalloproteinase, Ki-67 Protein, and Type II Collagen by Chondrocytes Migrating from Cartilage Endplate into Nucleus Pulposus in Rat Intervertebral Discs: A Cartilage Endplate-Fracture Model Using an Intervertebral Disc Organ Culture

Kim, Ki-Won; Ha, Kee-Yong; Park, Jong-Beom; More

Spine. 30(12):1373-1378, June 15, 2005.

An Autocrine or Paracrine Fas-Mediated Counterattack: A Potential Mechanism for Apoptosis of Notochordal Cells in Intact Rat Nucleus Pulposus

Kim, Ki-Won; Kim, Yong-Sik; Ha, Kee-Yong; More

Spine. 30(11):1247-1251, June 1, 2005.

Differential Effects of Fibronectin Fragment on Proteoglycan Metabolism by Intervertebral Disc Cells: A Comparison With Articular Chondrocytes

Aota, Yoichi; An, Howard S.; Homandberg, Gene; More

Spine. 30(7):722-728, April 1, 2005.

A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration

Masuda, Koichi; Aota, Yoichi; Muehleman, Carol; More

Spine. 30(1):5-14, January 1, 2005.

Intradiscal Administration of Osteogenic Protein-1 Increases Intervertebral Disc Height and Proteoglycan Content in the Nucleus Pulposus in Normal Adolescent Rabbits

An, Howard S.; Takegami, Kenji; Kamada, Hiroshi; More

Spine. 30(1):25-31, January 1, 2005.

Introduction: Disc Degeneration: Summary

An, Howard S.; Anderson, Paul A.; Haughton, Victor M.; More

Spine. 29(23):2677-2678, December 1, 2004.

Growth Factors and Treatment of Intervertebral Disc Degeneration

Masuda, Koichi; Oegema, Theodore R. Jr; An, Howard S.

Spine. 29(23):2757-2769, December 1, 2004.

Augmentation of Pedicle Screw Fixation Strength Using an Injectable Calcium Phosphate Cement as a Function of Injection Timing and Method

Renner, Susan M.; Lim, Tae-Hong; Kim, Whoan-Jeang; More

Spine. 29(11):E212-E216, June 1, 2004.

Enhancement of Stability Following Anterior Cervical Corpectomy: A Biomechanical Study

Singh, Kern; Vaccaro, Alexander R.; Kim, Jesse; More

Spine. 29(8):845-849, April 15, 2004.

Biomechanical Evaluation of Contemporary Posterior Spinal Internal Fixation Configurations in an Unstable Burst-fracture Calf Spine Model: Special References of Hook Configurations and Pedicle Screws

An, Howard S.; Singh, Kern; Vaccaro, Alexander R.; More

Spine. 29(3):257-262, February 1, 2004.

A Multicenter, Prospective, Randomized Trial Evaluating a New Hemostatic Agent for Spinal Surgery

Renkens, Kenneth L. Jr.; Payner, Troy D.; Leipzig, Thomas J.; More

Spine. 26(15):1645-1650, August 1, 2001.