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Articles by Gen Inoue, MD

Effect of Freeze-Dried Allograft Bone With Human Basic Fibroblast Growth Factor Containing a Collagen-Binding Domain From Clostridium histolyticum Collagenase on Bone Formation After Lumbar Posterolateral Fusion Surgery in Rats

Inoue, Gen; Uchida, Kentaro; Matsushita, Osamu; More

Spine. 42(17):E995-E1001, September 1, 2017.

Horizontal Fixation of the L3 Vertebra With a Tilt of Less Than 5° Can Prevent the Long-Term Curve Progression of Unfused Adult Scoliosis: Ten-Year Follow-up Study of Concave PLIF at the Wedged Disc Below the Caudal End Vertebra

Toyone, Tomoaki; Ozawa, Tomoyuki; Inada, Kunimasa; More

Spine. 40(5):312-315, March 01, 2015.

Inhibiting IκB Kinase-β Downregulates Inflammatory Cytokines in Injured Discs and Neuropeptides in Dorsal Root Ganglia Innervating Injured Discs in Rats

Kobori, Sayako; Miyagi, Masayuki; Orita, Sumihisa; More

Spine. 39(15):1171-1177, July 01, 2014.

Efficacy of Anti–Nerve Growth Factor Therapy for Discogenic Neck Pain in Rats

Sainoh, Takeshi; Sakuma, Yoshihiro; Miyagi, Masayuki; More

Spine. 39(13):E757-E762, June 01, 2014.

Upregulation of NaV1.7 in Dorsal Root Ganglia After Intervertebral Disc Injury in Rats

Sadamasu, Aya; Sakuma, Yoshihiro; Suzuki, Miyako; More

Spine. 39(7):E421-E426, April 01, 2014.

Evaluation of Pain Behavior and Calcitonin Gene-Related Peptide Immunoreactive Sensory Nerve Fibers in the Spinal Dorsal Horn After Sciatic Nerve Compression and Application of Nucleus Pulposus in Rats

Kimura, Seiji; Sakuma, Yoshihiro; Suzuki, Miyako; More

Spine. 39(6):455-462, March 15, 2014.

Dichotomizing Sensory Nerve Fibers Innervating Both the Lumbar Vertebral Body and the Area Surrounding the Iliac Crest: A Possible Mechanism of Referred Lateral Back Pain From Lumbar Vertebral Body

Fujii, Tatsuya; Sakuma, Yoshihiro; Orita, Sumihisa; More

Spine. 38(25):E1571-E1574, December 01, 2013.

Vertebral Compression Exacerbates Osteoporotic Pain in an Ovariectomy-Induced Osteoporosis Rat Model

Suzuki, Miyako; Orita, Sumihisa; Miyagi, Masayuki; More

Spine. 38(24):2085-2091, November 15, 2013.

Assessment of Pain Behavior in a Rat Model of Intervertebral Disc Injury Using the Catwalk Gait Analysis System

Miyagi, Masayuki; Ishikawa, Tetsuhiro; Kamoda, Hiroto; More

Spine. 38(17):1459-1465, August 01, 2013.

Short-Segment Fixation Without Fusion for Thoracolumbar Burst Fractures With Neurological Deficit Can Preserve Thoracolumbar Motion Without Resulting in Post-traumatic Disc Degeneration: A 10-Year Follow-up Study

Toyone, Tomoaki; Ozawa, Tomoyuki; Inada, Kunimasa; More

Spine. 38(17):1482-1490, August 01, 2013.

Comparison of CatWalk Analysis and von Frey Testing for Pain Assessment in a Rat Model of Nerve Crush Plus Inflammation

Sakuma, Takafumi; Kamoda, Hiroto; Miyagi, Masayuki; More

Spine. 38(15):E919-E924, July 01, 2013.

Comparison of Teriparatide and Bisphosphonate Treatment to Reduce Pedicle Screw Loosening After Lumbar Spinal Fusion Surgery in Postmenopausal Women With Osteoporosis From a Bone Quality Perspective

Ohtori, Seiji; Inoue, Gen; Orita, Sumihisa; More

Spine. 38(8):E487-E492, April 15, 2013.

Tumor Necrosis Factor-α-Immunoreactive Cells in Nucleus Pulposus in Adolescent Patients With Lumbar Disc Herniation

Ohtori, Seiji; Inoue, Gen; Eguchi, Yawara; More

Spine. 38(6):459-462, March 15, 2013.

Differences Between Tumor Necrosis Factor–α Receptors Types 1 and 2 in the Modulation of Spinal Glial Cell Activation and Mechanical Allodynia in a Rat Sciatic Nerve Injury Model

Ishikawa, Tetsuhiro; Miyagi, Masayuki; Kamoda, Hiroto; More

Spine. 38(1):11-16, January 01, 2013.

Difficulty of Diagnosing the Origin of Lower Leg Pain in Patients With Both Lumbar Spinal Stenosis and Hip Joint Osteoarthritis

Saito, Junya; Ohtori, Seiji; Kishida, Shunji; More

Spine. 37(25):2089-2093, December 01, 2012.

Acute Lumbar Spinal Pseudogout Attack After Instrumented Surgery

Ogawa, Yuya; Nagatsuma, Masahiro; Kubota, Gou; More

Spine. 37(24):E1529-E1533, November 15, 2012.

Teriparatide Accelerates Lumbar Posterolateral Fusion in Women With Postmenopausal Osteoporosis: Prospective Study

Ohtori, Seiji; Inoue, Gen; Orita, Sumihisa; More

Spine. 37(23):E1464-E1468, November 01, 2012.

ISSLS Prize Winner: Disc Dynamic Compression in Rats Produces Long-Lasting Increases in Inflammatory Mediators in Discs and Induces Long-Lasting Nerve Injury and Regeneration of the Afferent Fibers Innervating DiscsA Pathomechanism for Chronic Discogenic Low Back Pain

Miyagi, Masayuki; Ishikawa, Tetsuhiro; Kamoda, Hiroto; More

Spine. 37(21):1810-1818, October 01, 2012.

Platelet-Rich Plasma Combined With Hydroxyapatite for Lumbar Interbody Fusion Promoted Bone Formation and Decreased an Inflammatory Pain Neuropeptide in Rats

Kamoda, Hiroto; Yamashita, Masaomi; Ishikawa, Tetsuhiro; More

Spine. 37(20):1727-1733, September 15, 2012.

Sensory and Autonomic Innervation of the Cervical Intervertebral Disc in Rats: The Pathomechanics of Chronic Discogenic Neck Pain

Fujimoto, Kazuki; Miyagi, Masayuki; Ishikawa, Tetsuhiro; More

Spine. 37(16):1357-1362, July 15, 2012.

A Case of Symptomatic Extra-Foraminal Lumbosacral Stenosis (“Far-out Syndrome”) Diagnosed by Diffusion Tensor Imaging

Kitamura, Mitsuhiro; Eguchi, Yawara; Inoue, Gen; More

Spine. 37(14):E854-E857, June 15, 2012.

Investigation of Dichotomizing Sensory Nerve Fibers Projecting to the Lumbar Multifidus Muscles and Intervertebral Disc or Facet Joint or Sacroiliac Joint in Rats

Umimura, Tomotaka; Miyagi, Masayuki; Ishikawa, Tetsuhiro; More

Spine. 37(7):557-562, April 01, 2012.

Epidural Administration of Spinal Nerves With the Tumor Necrosis Factor-Alpha Inhibitor, Etanercept, Compared With Dexamethasone for Treatment of Sciatica in Patients With Lumbar Spinal Stenosis: A Prospective Randomized Study

Ohtori, Seiji; Miyagi, Masayuki; Eguchi, Yawara; More

Spine. 37(6):439-444, March 15, 2012.

Differences in Damage to CGRP Immunoreactive Sensory Nerves After Two Lumbar Surgical Approaches: Investigation Using Humans and Rats

Ohtori, Seiji; Miyagi, Masayuki; Takaso, Masashi; More

Spine. 37(3):168-173, February 01, 2012.

Lumbar Disc Degeneration Induces Persistent Groin Pain

Oikawa, Yasuhiro; Ohtori, Seiji; Koshi, Takana; More

Spine. 37(2):114-118, January 15, 2012.

Disk Injury in Rats Produces Persistent Increases in Pain-Related Neuropeptides in Dorsal Root Ganglia and Spinal Cord Glia but Only Transient Increases in Inflammatory Mediators: Pathomechanism of Chronic Diskogenic Low Back Pain

Miyagi, Masayuki; Ishikawa, Tetsuhiro; Orita, Sumihisa; More

Spine. 36(26):2260-2266, December 15, 2011.

Uni- and Bilateral Instrumented Posterolateral Fusion of the Lumbar Spine With Local Bone Grafting: A Prospective Study With a 2-Year Follow-up

Ohtori, Seiji; Koshi, Takana; Suzuki, Munetaka; More

Spine. 36(26):E1744-E1748, December 15, 2011.

Brain-Derived Neurotrophic Factor Inhibition at the Punctured Intervertebral Disc Downregulates the Production of Calcitonin Gene-Related Peptide in Dorsal Root Ganglia in Rats

Orita, Sumihisa; Eguchi, Yawara; Kamoda, Hiroto; More

Spine. 36(21):1737-1743, October 1, 2011.

Assessment of Gait in a Rat Model of Myofascial Inflammation Using the CatWalk System

Miyagi, Masayuki; Ishikawa, Tetsuhiro; Kamoda, Hiroto; More

Spine. 36(21):1760-1764, October 1, 2011.

One, Two-, and Three-Level Instrumented Posterolateral Fusion of the Lumbar Spine With a Local Bone Graft: A Prospective Study With a 2-Year Follow-up

Inage, Kazuhide; Ohtori, Seiji; Koshi, Takana; More

Spine. 36(17):1392-1396, August 01, 2011.

Surgical Versus Nonsurgical Treatment of Selected Patients With Discogenic Low Back Pain: A Small-Sized Randomized Trial

Ohtori, Seiji; Koshi, Takana; Yamashita, Masaomi; More

Spine. 36(5):347-354, March 1, 2011.

Diffusion Magnetic Resonance Imaging to Differentiate Degenerative From Infectious Endplate Abnormalities in the Lumbar Spine

Eguchi, Yawara; Ohtori, Seiji; Yamashita, Masaomi; More

Spine. 36(3):E198-E202, February 1, 2011.

Direct Application of the Tumor Necrosis Factor-α Inhibitor, Etanercept, Into a Punctured Intervertebral Disc Decreases Calcitonin Gene-Related Peptide Expression in Rat Dorsal Root Ganglion Neurons

Horii, Manato; Orita, Sumihisa; Nagata, Maiko; More

Spine. 36(2):E80-E85, January 15, 2011.

18F-Fluorodeoxyglucose-PET for Patients With Suspected Spondylitis Showing Modic Change

Ohtori, Seiji; Suzuki, Munetaka; Koshi, Takana; More

Spine. 35(26):E1599-E1603, December 15, 2010.

The Effects of Risedronate and Exercise on Osteoporotic Lumbar Rat Vertebrae and Their Sensory Innervation

Orita, Sumihisa; Ohtori, Seiji; Koshi, Takana; More

Spine. 35(22):1974-1982, October 15, 2010.

Radiographic Evaluation of Monocortical Versus Tricortical Purchase Approaches in Lumbosacral Fixation With Sacral Pedicle Screws: A Prospective Study of Ninety Consecutive Patients

Orita, Sumihisa; Ohtori, Seiji; Eguchi, Yawara; More

Spine. 35(22):E1230-E1237, October 15, 2010.

Subsequent Vertebral Fractures Following Spinal Fusion Surgery for Degenerative Lumbar Disease: A Mean Ten-Year Follow-up

Toyone, Tomoaki; Ozawa, Tomoyuki; Kamikawa, Koya; More

Spine. 35(21):1915-1918, October 1, 2010.

Direct Evidence for Sensory Innervation of the Dorsal Portion of the Co5/6 Coccygeal Intervertebral Disc in Rats

Orita, Sumihisa; Ohtori, Seiji; Taniguchi, Aya; More

Spine. 35(14):1346-1352, June 15, 2010.

Low Back Pain After Lumbar Discectomy in Patients Showing Endplate Modic Type 1 Change

Ohtori, Seiji; Yamashita, Masaomi; Yamauchi, Kazuyo; More

Spine. 35(13):E596-E600, June 1, 2010.

Change in Modic Type 1 and 2 Signals After Posterolateral Fusion Surgery

Ohtori, Seiji; Yamashita, Masaomi; Yamauchi, Kazuyo; More

Spine. 35(12):1231-1235, May 20, 2010.

Direct Single Injection of p38 Mitogen-Activated Protein Kinase Inhibitor Does Not Affect Calcitonin Gene-Related Peptide Expression in Dorsal Root Ganglion Neurons Innervating Punctured Discs in Rats

Hayashi, Yasushi; Ohtori, Seiji; Yamashita, Masaomi; More

Spine. 34(26):2843-2847, December 15, 2009.

Nerve Growth Factor of Cultured Medium Extracted From Human Degenerative Nucleus Pulposus Promotes Sensory Nerve Growth and Induces Substance P In Vitro

Yamauchi, Kazuyo; Inoue, Gen; Koshi, Takana; More

Spine. 34(21):2263-2269, October 1, 2009.

Results of Surgery for Discogenic Low Back Pain: A Randomized Study Using Discography Versus Discoblock for Diagnosis

Ohtori, Seiji; Kinoshita, Tomoaki; Yamashita, Masaomi; More

Spine. 34(13):1345-1348, June 1, 2009.

Long-term Intravenous Administration of Antibiotics for Lumbar Spinal Surgery Prolongs the Duration of Hospital Stay and Time to Normalize Body Temperature After Surgery

Ohtori, Seiji; Inoue, Gen; Koshi, Takana; More

Spine. 33(26):2935-2937, December 15, 2008.

Direct Application of the TNF-Alpha Inhibitor, Etanercept, Does Not Affect CGRP Expression and Phenotypic Change of DRG Neurons Following Application of Nucleus Pulposus Onto Injured Sciatic Nerves in Rats

Norimoto, Masaki; Ohtori, Seiji; Yamashita, Masaomi; More

Spine. 33(22):2403-2408, October 15, 2008.

Existence of Nerve Growth Factor Receptors, Tyrosine Kinase A and p75 Neurotrophin Receptors in Intervertebral Discs and on Dorsal Root Ganglion Neurons Innervating Intervertebral Discs in Rats

Sugiura, Ai; Ohtori, Seiji; Yamashita, Masaomi; More

Spine. 33(19):2047-2051, September 1, 2008.

Tumor Necrosis Factor-Alpha in the Nucleus Pulposus Mediates Radicular Pain, but Not Increase of Inflammatory Peptide, Associated With Nerve Damage in Mice

Yamashita, Masaomi; Ohtori, Seiji; Koshi, Takana; More

Spine. 33(17):1836-1842, August 1, 2008.

TNF-Alpha in Nucleus Pulposus Induces Sensory Nerve Growth: A Study of the Mechanism of Discogenic Low Back Pain Using TNF-Alpha–Deficient Mice

Hayashi, Shinu; Taira, Akiko; Inoue, Gen; More

Spine. 33(14):1542-1546, June 15, 2008.

Rho Kinase Inhibitor Improves Motor Dysfunction and Hypoalgesia in a Rat Model of Lumbar Spinal Canal Stenosis

Ito, Toshinori; Ohtori, Seiji; Hata, Katsuhiko; More

Spine. 32(19):2070-2075, September 1, 2007.

Sensory Innervation of Lumbar Vertebral Bodies in Rats

Ohtori, Seiji; Inoue, Gen; Koshi, Takana; More

Spine. 32(14):1498-1502, June 15, 2007.

Glial Phosphorylated p38 MAP Kinase Mediates Pain in a Rat Model of Lumbar Disc Herniation and Induces Motor Dysfunction in a Rat Model of Lumbar Spinal Canal Stenosis

Ito, Toshinori; Ohtori, Seiji; Inoue, Gen; More

Spine. 32(2):159-167, January 15, 2007.

Substance P-Saporin Down-Regulates Substance P Receptor Immunoreactive Sensory Dorsal Root Ganglion Neurons Innervating the Lumbar Intervertebral Discs in Rats

Ohtori, Seiji; Inoue, Gen; Koshi, Takana; More

Spine. 31(26):2987-2991, December 15, 2006.

Injection of Nuclear Factor-Kappa B Decoy into the Sciatic Nerve Suppresses Mechanical Allodynia and Thermal Hyperalgesia in a Rat Inflammatory Pain Model

Inoue, Gen; Ochiai, Nobuyasu; Ohtori, Seiji; More

Spine. 31(25):2904-2908, December 1, 2006.

The Degenerated Lumbar Intervertebral Disc is Innervated Primarily by Peptide-Containing Sensory Nerve Fibers in Humans

Ozawa, Tomoyuki; Ohtori, Seiji; Inoue, Gen; More

Spine. 31(21):2418-2422, October 1, 2006.

Up-Regulation of Acid-Sensing Ion Channel 3 in Dorsal Root Ganglion Neurons Following Application of Nucleus Pulposus on Nerve Root in Rats

Ohtori, Seiji; Inoue, Gen; Koshi, Takana; More

Spine. 31(18):2048-2052, August 15, 2006.

Exposure of the Nucleus Pulposus to the Outside of the Anulus Fibrosus Induces Nerve Injury and Regeneration of the Afferent Fibers Innervating the Lumbar Intervertebral Discs in Rats

Inoue, Gen; Ohtori, Seiji; Aoki, Yasuchika; More

Spine. 31(13):1433-1438, June 1, 2006.

Tumor Necrosis Factor-Immunoreactive Cells and PGP 9.5-Immunoreactive Nerve Fibers in Vertebral Endplates of Patients With Discogenic Low Back Pain and Modic Type 1 or Type 2 Changes on MRI

Ohtori, Seiji; Inoue, Gen; Ito, Toshinori; More

Spine. 31(9):1026-1031, April 20, 2006.

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