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Assessment of Association Between Low Back Pain and Paraspinal Muscle Atrophy Using Opposed-Phase Magnetic Resonance Imaging: A Population-Based Study Among Young Adults

Paalanne, Niko, MD*,†; Niinimäki, Jaakko, MD, PhD; Karppinen, Jaro, MD, PhD*,§; Taimela, Simo, MD, PhD; Mutanen, Pertti, MSc; Takatalo, Jani, MSc, BM*; Korpelainen, Raija, PhD†,[BULLET OPERATOR],**; Tervonen, Osmo, MD, PhD

doi: 10.1097/BRS.0b013e3181fef890
Diagnostics
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Study Design. A cross-sectional imaging study of young adults.

Objective. To evaluate whether severity of low back symptoms predicts atrophy in the paraspinal muscles of young adults.

Summary of Background Data. Although an increased fat content of the lumbar muscles has been observed among adults with chronic LBP, there is limited knowledge of this association in younger populations.

Methods. The population-based study sample consisted of 554 subjects (321 females and 233 males) from the 1986 Northern Finland Birth Cohort. Latent Class Analysis (LCA) was used to cluster the subjects according to the low back symptoms and functional limitations at 18, 19, and 21 years. The mean age of the subjects at the time of the MRI (magnetic resonance imaging) was 21 years (range, 20–23). Muscle atrophy was evaluated by assessing the fat content of the paraspinal muscles using Opposed-Phase MRI. The cross-sectional areas (CSAs) of the erector spinae and multifidus muscles were also measured.

Results. LCA analysis produced five clusters differing in symptoms, ranging from a cluster (n = 65) in which subjects had high likelihood of symptoms and functional limitations at all time points, to a cluster (n = 165) with no pain ever. The fat content of the multifidus muscles was significantly higher among women than men (14.0% vs. 5.3%, P < 0.001), but it was not significantly associated with symptom severity. The CSA of both erector spinae and multifidus muscles were significantly larger among men than women (P < 0.001 in all of the muscles), but were not associated with pain severity.

Conclusion. Low back symptoms and functional limitations over a 3-year period were not associated with increased fat content or a reduction in the cross-sectional area of lumbar paraspinal muscles among young adults.

A population-based cohort of 554 young adults was clustered according to low back symptoms and functional limitations at 18, 19, and 21 years. Low back symptom severity did not associate with paraspinal muscle atrophy, that is, multifidus fat content using Opposed-Phase magnetic resonance imaging or cross-sectional area of erector spinae and multifidus muscles, at a mean age of 21 years.

*Department of Physical and Rehabilitation Medicine, Institute of Clinical Medicine, University of Oulu, Oulu, Finland;

Department of Sports and Exercise Medicine, Oulu Deaconess Institute, Oulu, Finland;

Institute of Diagnostics, Department of Diagnostic Radiology, University of Oulu, Oulu, Finland;

§Finnish Institute of Occupational Health, Oulu, Finland;

Department of Public Health, University of Helsinki, Helsinki, Finland;

[BULLET OPERATOR]Institute of Health Sciences, University of Oulu, Oulu, Finland;

**Institute of Biomedicine, Department of Medical Technology, University of Oulu, Oulu, Finland.

Address correspondence and reprint requests to Jaro Karppinen, MD, PhD, Finnish Institute of Occupational Health, Aapistie 1, 90220 Oulu, Finland; E-mail: jaro.karppinen@ttl.fi

Acknowledgement date: June 23, 2010. Revision date: September 26, 2010. Acceptance date: September 27, 2010.

The manuscript submitted does not contain information about medical device(s)/drug(s).

Grant funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

This study was supported by grants from the Academy of Finland (Dr. Karppinen; #200868).

© 2011 Lippincott Williams & Wilkins, Inc.