The Natural Course of Acute Sciatica with Nerve Root Symptoms in a Double-Blind Placebo-Controlled Trial Evaluating the Effect of PiroxicamWeber, Henrik, MD; Holme, Ingar, PhD; Amlie, Even, MDSpine: September 1993 - Volume 18 - Issue 11 - p 1433–1438 The Natural Course of Acute Sciatica with Nerve Root Symptoms in a Double-Blind Placebo-Controlled Trial Evaluating the Effect of Piroxicam: PDF Only Buy Abstract Author InformationAuthors To study the natural history of acute sciatica, 208 patients with obvious symptoms and signs of a lumbar radiculopathy (L5 and S1) were examined within 14 days of onset. A concomitant double-blind investigation of the effect of the nonsteroidal anti-inflammatory drug piroxicam was performed. The results measured by visual analog scale and Roland's functional tests showed a satisfactory improvement throughout the 4 weeks of observation. The piroxicam-treated group had same results as the control group. Based on questionnaires at months 3 and 12 approximately 30% of the patients still complained about back trouble and 19.5% were out of work after 1 year. Four patients underwent surgery during this period. From the Neurological Department, Life Insurance Companies' Institute for Medical Statistics at Ullevaal Hospital, Oslo, and Norsk Hydro A/S Porsgrunn, Norway. Accepted for publication March 29, 1993. © Lippincott-Raven Publishers.