Retrospective study of prospectively collected data.
To determine the incidence, timing, risk factors, and clinical implications of postoperative hematoma requiring reoperation after anterior cervical discectomy and fusion (ACDF).
Postoperative hematomas requiring reoperation are rare but potentially catastrophic complications after ACDF. However, there has been a lack of large cohort studies investigating these complications in the ACDF population despite increasing outpatient procedure volume.
Patients who underwent ACDF in the 2012 to 2016 National Surgical Quality Improvement Program database were identified. The primary outcome was an occurrence of hematoma requiring reoperation within 30 days postoperatively. Risk factors for this outcome were identified using multivariate regression. Postoperative length of stay, subsequent complications, and mortality were compared between patients who did and did not develop a hematoma requiring reoperation.
A total of 37,261 ACDF patients were identified, of which 148 (0.40%) developed a hematoma requiring reoperation (95% confidence interval [CI], 0.33%–0.46%). Of the cases that developed this complication, 37% occurred after discharge. Risk factors for the development of hematoma requiring reoperation were multilevel procedures (most notably ≥3 levels, relative risk [RR] = 3.14, 95% CI = 1.86–5.32, P < 0.001), preoperative international normalized ratio >1.2 (RR = 2.85, 95% CI = 1.42–5.71, P = 0.006), lower BMI (notably body mass index ≤24, RR = 2.11, 95% CI = 1.21–3.67, P = 0.008), American Society of Anesthesiologists classification ≥3 (RR = 2.07, 95% CI = 1.47–2.91, P < 0.001), preoperative anemia (RR = 1.71, 95% CI = 1.12–2.63, P = 0.027), and male sex (RR = 1.67, 95% CI = 1.18–2.37, P = 0.004). In addition, patients who developed a hematoma requiring reoperation before discharge had a longer length of stay. Further, those who developed a hematoma requiring reoperation were at higher risk for subsequent ventilator requirement, deep wound infection, pneumonia, and reintubation.
Postoperative hematoma requiring reoperation occurred in approximately 1 in 250 patients after ACDF. High-risk patients should be closely monitored through the perioperative period.
Level of Evidence: 3
Among 37,261 ACDF procedures, the incidence of postoperative hematoma requiring reoperation was 0.40%, of which 37% occurred post-discharge. Risk factors were multi-level procedures, high preoperative INR, low BMI, high ASA, preoperative anemia, and male gender. These patients were at higher risk for other adverse events.
∗Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT
†Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY
‡Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.
Address correspondence and reprint requests to Jonathan N. Grauer, MD, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, 47 College Street, New Haven, CT 06520; E-mail: firstname.lastname@example.org
Received 11 July, 2018
Accepted 31 August, 2018
The manuscript submitted does not contain information about medical device(s)/drug(s).
Yale School of Medicine Medical Student Research Fellowship at Yale School of Medicine funds were received in support of this work.
Relevant financial activities outside the submitted work: board membership, consultancy, royalties, stocks, grants, expert testimony, employment.
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