We collected the samples of cervical intervertebral discs from patients with vertigo
to examine the distribution and types of mechanoreceptors in diseased cervical disc.
The aim of this study was to determine whether mechanoreceptors are distributed more abundantly in cervical discs from patients with cervical spondylosis
, and whether they are related to vertigo
Summary of Background Data.
Previous limited studies have found that normal cervical intervertebral discs are supplied with mechanoreceptors that have been considered responsible for proprioceptive functions. Several clinical studies have indicated that the patients with cervical spondylosis
manifested significantly impaired postural control and subjective balance disturbance.
We collected 77 samples of cervical discs from 62 cervical spondylosis
patients without vertigo
, 61 samples from 54 patients with vertigo
, and 40 control samples from 8 cadaveric donors to investigate distribution of mechanoreceptors containing neurofilament (NF200) and S-100 protein immunoreactive nerve endings.
The immunohistochemical investigation revealed that the most frequently encountered mechanoreceptors were the Ruffini corpuscles
in all groups of cervical disc samples. They were obviously increased in the number and deeply ingrown into inner annulus fibrosus and even into nucleus pulposus in the diseased cervical discs from patients with vertigo
in comparison with the discs from patients without vertigo
and control discs. Only three Golgi endings were seen in the three samples from patients with vertigo
. No Pacinian corpuscles were found in any samples of cervical discs.
The diseased cervical discs from patients with vertigo
had more abundant distribution of Ruffini corpuscles
than other discs. A positive association between the increased number and ingrowth of Ruffini corpuscles
in the diseased cervical disc and the incidence of vertigo
in the patients with cervical spondylosis
was found, which may indicate a key role of Ruffini corpuscles
in the pathogenesis
of cervical origin.
Level of Evidence: 1