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Predicting Neurologic Recovery after Surgery in Patients with Deficits Secondary to MESCC

Systematic Review

Laufer, Ilya, MD; Zuckerman, Scott L., MD; Bird, Justin E., MD; Bilsky, Mark H., MD; Lazáry, Áron, MD, PhD§; Quraishi, Nasir A., LLM; Fehlings, Michael G., MD, PhD||; Sciubba, Daniel M., MD∗∗; Shin, John H., MD††; Mesfin, Addisu, MD‡‡; Sahgal, Arjun, MD§§; Fisher, Charles G., MD, MHSc¶¶

doi: 10.1097/BRS.0000000000001827
METASTATIC SPINE TUMORS
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SDC

Study Design. Systematic literature review and expert survey

Objective. The aim of this study was to determine factors associated with neurologic improvement in patients with neurologic deficits secondary to metastatic epidural spinal cord compression (MESCC). Clear understanding of these factors will guide surgical decision-making by helping to elucidate which patients are more likely to benefit from surgery and how surgeons can increase the probability of neurologic and functional restoration.

Summary of Background Data. Surgical spinal cord decompression has been shown to improve neurologic function in patients with symptomatic MESCC. However, prognostication of neurologic improvement after surgery remains challenging, owing to sparse data and complexity of these patients.

Methods. PubMed and Embase databases were searched for relevant publications. PRISMA Statement guided publication selection and data reporting. GRADE guidelines were used for evidence quality evaluation and recommendation formulation.

Results. Low-quality evidence supports the use of the duration and severity of neurologic deficit as predictors of neurological recovery in patients with MESCC. Low-quality evidence supports the use of thoracic level of compression and previous irradiation as adverse predictors of neurological recovery. Nearly all of the AOSpine Knowledge Forum Tumor members who responded to the survey agreed that ambulation with assistance represented a successful surgical result and that duration of ambulation loss and the severity of weakness should be considered when trying to predict whether surgery would result in restoration of ambulation.

Conclusions. Review of literature and expert opinion support the importance of duration of ambulation loss and the severity of neurologic deficit (muscle strength, bladder function) in prediction of neurologic recovery among patients with symptomatic MESCC. Efforts to reduce the duration of ambulation loss and to prevent progression of neurologic deficits should be made to improve the probability of neurologic recovery.

Level of Evidence: 2

Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, New York, NY

Department of Neurological Surgery, Vanderbilt University School of Medicine, Nashville, TN

Department of Orthopaedic Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

§National Center for Spinal Disorders, Budapest, Hungary

Centre for Spinal Studies & Surgery, Nottingham University Hospital, Queens Medical Center Campus, Nottingham, UK

||Division of Neurosurgery, Department of Surgery, University of Toronto and Toronto, Western Hospital, Toronto, Ontario, Canada

∗∗Department of Neurological Surgery, Johns Hopkins University School of Medicine, Baltimore, MD

††Department of Neurosurgery, Massachusetts General Hospital, Boston, MA

‡‡Department of Orthopaedic Surgery and Oncology, University of Rochester Medical Center, Rochester, NY

§§Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

¶¶Department of Orthopaedics, Division of Spine, University of British Columbia and Vancouver General Hospital, Vancouver, BC, Canada.

Address correspondence and reprint requests to Ilya Laufer, MD, Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue New York, New York 10065; E-mail: lauferi@mskcc.org

Received 27 April, 2016

Revised 3 July, 2016

Accepted 12 July, 2016

The manuscript submitted does not contain information about medical device(s)/drug(s).

AOSpine International funds were received in support of this work.

Relevant financial activities outside the submitted work: grants.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.spinejournal.com).

Spinal surgery remains an integral treatment component in the continuously shifting landscape of managing patients with metastatic cancer.1–4 The goals of surgery in patients with metastatic epidural spinal cord compression (MESCC) include restoration and preservation of neurologic function, and spinal stability and pain relief. The functional status of cancer patients correlates with quality of life and survival, with ambulatory patients surviving longer than patients who have lost the ability to ambulate.3,5 Ambulation also serves as a requisite for further systemic therapy and inclusion in clinical trials, further supporting the significance of neurologic preservation and restoration.

It has been observed that preoperative ambulation status is one of the strongest and most consistent predictors of postoperative ambulation and that surgery is a valuable intervention in preservation of ambulation among patients without profound neurologic deficits.6,7 However, the challenge lies in identifying the most appropriate patient for surgery. The variety of neurologic deficits that can occur secondary to MESCC, variation in the severity of spinal cord dysfunction, and the heterogeneity of the patient population have resulted in a lack of clear understanding of what are the most important predictive factors specific to neurologic recovery. The objective of the current study is to determine which factors are associated with neurologic improvement in patients with neurologic deficits secondary to MESCC and to improve patient selection for surgery.

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MATERIALS AND METHODS

Question Definition

Patient population: MESCC causing neurologic impairment

Intervention: Surgery

Outcome: Neurological recovery

Subgroup Analysis: Preoperative prognostic indicators associated with postoperative neurologic improvement

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Study Question

In patients with metastatic spine disease-causing neurological impairment, what are the preoperative prognostic indicators for neurological recovery after surgery?

PubMed and Embase databases were searched using the following search strategy: metastatic spine AND prognosis AND neurological outcome OR “metastatic spinal cord compression” AND (ambulation or continence or spinal cord injury or ASIA). Initial search results were screened based on publication titles and abstracts and restricted to English-language publications. Subsequently full-text articles of interest were assessed for inclusion of appropriate patient population and reporting of information that addressed the intervention, outcome, and subgroup analysis stated in the question definition above. Bibliographies were also screened for relevant publications that were not found during the database searches. Data included in the current publication were extracted and reconciled by 2 authors (IL and SZ). The PRISMA Statement checklist and information flow diagram were used to ensure clear description of the publication selection and data-reporting process.8

GRADE guidelines were used for evaluation of evidence quality, recommendation formulation, and determination of recommendation strength as seen in Box 1.9,10 Observational publications included in the current review were all initially classified as low quality of evidence. GRADE criteria for lowering or raising the rating of evidence quality were used to evaluate the association between individual preoperative variables and neurologic recovery.

Box 1

Box 1

Survey of AOSpine Knowledge Forum Tumor members was conducted (Supplemental Table 2, http://links.lww.com/BRS/B198). The purpose of the survey was to define the specific outcomes of interest when discussing postoperative neurologic function and to determine which preoperative patient variables affect surgical decision-making in expert clinical practice. Questions about the neurologic outcomes of interest were derived based on the data endpoints reported in the MESCC treatment literature.

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RESULTS

Literature Search

Initial search produced 312 publications and 310 remained after removing duplicate records. The abstracts of these publications were screened and 204 publications were excluded. One hundred and six full-text articles were assessed for eligibility and seven articles met the inclusion criteria. Reasons for exclusion are provided in Figure 1. All of the included publications reported retrospectively collected patient data (Supplementary Supplement Table 1, http://links.lww.com/BRS/B198). Putz et al11 and Furstenberg et al12 studied the same patient population.

Figure 1

Figure 1

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Duration of Symptoms

Five articles reported an association between the duration of symptom onset and neurologic improvement after surgery. Four of these publications dichotomized time and used 48 hours as the cut-point. Chaichana et al studied 23 nonambulatory patients and reported a relative risk (RR) of ambulation recovery of 2.9 (1.13–2.93, P < 0.02) in patients with <48 hours between symptom onset and surgery. The mean duration of symptoms was 18 days (SD 18 days) among patients who regained ambulation and 48 days (SD 54 days) among patients who did not recover.7 Crnalic et al13 studied patients with MESCC secondary to prostate cancer and found that patients with <48 hours between loss of ambulation and surgery were more likely to be ambulatory 4 weeks after surgery. Among patients who regained ambulation, the median nonambulatory duration was 1 day (range 1–3 days) and it was 2 days (range 0–7) in the group without ambulation restoration (P < 0.002). Sixty-four percent of patients (18/28) with <48 hours between loss of ambulation and surgery recovered ambulation, whereas only 18% (3/17) regained ambulation after a longer time to surgery (P < 0.005). Furstenberg et al12 studied the effect of the timing of surgical decompression in 35 patients with neurologic deficits due to MESCC. Among 21 patients who underwent surgical decompression within 48 hours of symptom onset, 71% experienced improvement of their ASIA score and 29% remained stable. However, in the group that underwent surgery >48 hours after symptom onset, only 29% improved, with 43% remaining the same and 29% deteriorating (P < 0.01). Quraishi et al14 reported that among 121 patients with neurologic deficits secondary to MESCC, there was a negative correlation between the time from deficit presentation to surgery and the change in Frankel grade (Kendall tau rank correlation coefficient, r = −0.176). They also reported that patients who underwent surgery within 48 hours of symptom onset experienced greater improvement in the Frankel grade, compared to patients who underwent surgery >48 hours after symptom onset (P < 0.05). Seven percent of patients suffered neurologic deterioration in the former group, whereas 13% deteriorated in the latter group. Hessler et al operated on 194 patients with neurologic deficits owing to spinal metastases and evaluated preoperative and postoperative Frankel scores that were measured 5 to 7 days after surgery.15 They reported a significant correlation between the preoperative duration of symptoms and the postoperative neurologic outcome (P < 0.01, Kendall-τ b = −0.331), and patients with symptom duration of <10 days and <3 days having higher probability of neurologic improvement compared to patients with >15 days symptom duration. The duration of symptoms did not appear to correlate with the probability of neurologic deterioration.

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Severity of Preoperative Neurologic Deficit

Two neurologic findings associated with neurologic recovery were reported. Furstenberg et al12 reported an association between preoperative bladder function and ASIA score improvement. Among 20 patients with normal bladder function, 45% showed improvement in their ASIA score, 45% remained the same, and 10% deteriorated. However, among 15 patients with bladder dysfunction, 93% of patients remained the same and 7% deteriorated. Park et al16 treated 102 patients with MESCC at thoracic level causing lower extremity weakness. Patients with Grade III or better muscle strength were much more likely to ambulate 48 hours after surgery compared to patients with more profound weakness (odds ratio [OR] 49.2, confidence interval [CI] 18.4–167.8, P < 0.001). Among nonambulatory patients, 86% of patients recovered ability to ambulate if their muscle strength was Grade III or better, whereas only 22% recovered if their muscle strength was I or II. Furthermore, the data reported by Hessler et al indirectly support the association between the severity of preoperative neurologic deficit and postoperative recovery.15 They reported that 40.2% of patients neurologically improved after surgery, with 37.6% improving by one Frankel grade and 2.6% improving by 2 grades. Therefore, patients with Frankel scores C or D were much more likely to ambulate postoperatively.

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Radiographic Parameters

Two radiographic finding associated with ambulation recovery were reported. Chaichana et al17 reported that there was a trend toward significance in the association between the presence of vertebral compression fracture (VCF) and ambulation recovery. Patients with VCF were possibly less likely to regain ambulation (OR 2.5, CI 0.85–9.94, P = 0.14), with 50% of nonambulatory patients without VCF regaining ambulation compared to 35% of patients with VCF (P < 0.09). In a separate publication, Chaichana et al7 reported a trend toward a significant association between the level of compression and ambulation recovery, with patients with thoracic levels of compression less likely to regain ambulation (RR 0.003, CI 0.001–1.113, p < 0.07).

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Local and Systemic Oncologic Considerations

The aggressiveness of the tumor causing MESCC and of systemic disease may also be associated with ambulation recovery after surgery. Tumor progression after radiation therapy may be adversely associated with recovery of ambulation after surgery. Chaichana et al7 reported that preoperative radiotherapy serves as a negative predictor of postoperative ambulation recovery (RR 0.41, P < 0.03). Crnalic et al13 reported that among patients with MESCC owing to prostate cancer, the severity of systemic disease was associated with ambulation recovery after surgery. Seventy-nine percent of patients with hormone-naïve prostate cancer recovered ambulation compared to 46% of patients with hormone resistance (P < 0.037). Furthermore, 64% of patients with prostate-specific antigen (PSA) level <200 ng/mL recovered ambulation, compared to 29% with PSA ≥200 ng/mL (P < 0.036). Finally, Putz et al11 reported an association between the preoperative Tokuhashi score and the change in ASIA Impairment Scale (AIS). Patients with AIS improvement had mean Tokuhashi score of 9, the group with no change had mean score of 8, and the group with AIS deterioration had a score of 7 (r = 0.33, P < 0.048). However, a larger series from the same institution did not support the association between the preoperative Tokuhashi score and neurologic improvement (Putz 2014).

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Survey

Forty-one members of the AOSpine Knowledge Forum Tumor received invitations to complete the survey with 32 people responding (78% response rate). Among the respondents, 94% were surgeons and 6% were radiation oncologists, with median practice duration of 8 years (1–38 range). Survey questions and response distribution are included in Supplemental Table 2, http://links.lww.com/BRS/B198.

Survey results indicated that satisfactory outcomes of surgery included improvement in muscle strength or preservation of bowel/bladder function even without recovery of ambulation (69% and 90% of respondents, respectively). Ninety-seven percent of respondents agreed that ambulation with assistance or walking aids represented a successful surgical result. Although the responses regarding minimal desired distance of ambulation lacked consensus, 53% indicated that at least 4 meters of ambulation were required to qualify as meaningful ambulation.

The panel unanimously agreed that the duration of ambulation loss should be considered when trying to predict whether surgery would result in restoration of ambulation. Forty-one percent of participants did not think that prolonged duration of ambulation loss should exclude the patient from consideration for surgery, whereas 13% responded that they would exclude patients from surgery after 24 hours of ambulation loss. Sixty-nine percent of participants stated that patients were less likely to recover ambulation after 48 hours of ambulation loss.

Ninety-four percent of the respondents agreed that the severity of weakness should be considered when trying to predict whether patients would recover ambulation after surgery. Forty percent of the panel stated that MRC grade 0 in bilateral lower extremities should exclude patients from undergoing surgery, and additional 23% used MRC grade of 1 as exclusion criterion.

Questions about the importance of age, level of spinal cord compression, the number of contiguous compressed spinal levels, presence of VCF, and radiation therapy history did not result in consensus about the value of these variables in prediction of postoperative neurologic recovery.

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DISCUSSION

Primary goals of treatment in patients with MESCC include preservation or restoration of neurologic function and spinal stability, local tumor control, and pain relief. Clear understanding of treatment goals and which variables are associated with attainment of these goals can significantly facilitate therapeutic decision-making.

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Variables Associated With Neurologic Recovery

Duration of Symptoms

Data consistently indicate that the duration of time between the onset of neurologic deficit and surgery adversely affects the probability of neurologic improvement and possibly places the patients at risk of neurologic deterioration and the survey of AOSpine Knowledge Forum Tumor members unanimously confirmed the importance of symptom duration in prognostication of postoperative neurologic recovery. Low quality of evidence supports the association between neurologic recovery and the duration of neurologic symptoms before surgery.

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Severity of Preoperative Neurologic Deficit

Two studies demonstrated a strong association between the severity of preoperative neurologic deficit and postoperative neurologic recovery. These data suggest that preoperative bladder dysfunction serves as a negative prognostic indicator of postoperative neurologic improvement and that MRC muscle strength ≥III serves as a strong predictor of ambulation recovery. Low quality of evidence supports the association of preoperative bladder dysfunction and motor deficit with postoperative neurologic improvement. This association is further supported by the data from numerous publications reporting the association between preoperative ambulation and postoperative ambulation.

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Radiographic Parameters

Trends toward adverse association between the presence of VCF and the thoracic level of compression were reported; however, it did not reach statistical significance (P < 0.09), resulting in very low quality of evidence in support of this association. Although the probability of ambulation recovery was dramatically lower in patients with thoracic MESCC compared to the cervical and lumbar levels (RR 0.003 compared to cervical level), the association failed to reach statistical significance on multivariate analysis (P < 0.07). The large reported magnitude of effect may support the upgrading of evidence quality to low from very low.

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Local and Systemic Oncologic Considerations

One publication reported preoperative radiation therapy as an adverse prognostic indicator of ambulation recovery (RR 0.4). In patients with history of radiation therapy, the time interval shorter than a week between radiotherapy and surgery at the irradiated site has been shown to be associated with increased risk of postoperative wound complication and neurologic deterioration.18 Details about the timing and intent of preoperative radiotherapy, along with the radiation dose and postoperative tumor control, would likely play a role in better understanding of the relationship between preoperative radiotherapy and neurologic recovery. Low-quality evidence supports preoperative radiotherapy as an adverse prognostic indicator of neurologic recovery.

The association between the Tokuhashi score and postoperative ASIA score improvement was reported in one publication with a small magnitude of effect. Furthermore, this association was not replicated in a larger series from the same institution, resulting in very low quality of evidence supporting the association between the Tokuhashi score and postoperative neurologic recovery. Finally, among patients with loss of ambulation owing to prostate cancer MESCC, PSA level and hormone status served as a predictor of ambulation recovery. The severity and treatment responsiveness of cancer likely play a role in the postoperative local control and the overall functional status of the patient, thereby affecting the ability to undergo rehabilitation therapy and to achieve neurologic recovery after surgery. Among patients with prostate cancer, low-quality evidence supports the role of PSA level and hormone status as predictors of neurologic recovery. Considering the rapidly evolving options for systemic therapy in cancer patients and the changing histology-specific survival profiles, our ability to use cancer-specific predictors of neurologic recovery is limited.

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Clinical Application of Prognostic Variables

The current systematic literature review and expert survey revealed only two factors partially amenable to physician control: duration and severity of neurologic deficit. The duration of preoperative deficit may be divided into two time intervals: time from deficit onset to physician evaluation and time between physician evaluation and surgery. Patient and physician education about early reporting and detection of neurologic deficits may result in earlier diagnosis and treatment of MESCC. Current data support making every effort to decrease the duration of neurologic deficit, indicating that once the decision is made to operate on a patient with neurologic dysfunction due to MESCC, surgery should take place as soon as possible under the safest possible circumstances. The value of expedited surgery probably decreases as the duration of deficit increases and we must rely on the judgment of the physicians to determine the optimal timing of surgery.

Low-quality evidence supports the association between the severity of neurologic deficit before surgery and postoperative neurologic recovery. In the overwhelming majority of cases, patients with MESCC present to medical attention with a static rather than progressive neurologic deficit. In the rare cases with progressive neurologic deficit, expedited surgical decompression may prevent progression of the neurologic deficit to loss of ambulation, bladder dysfunction, and MRC grade ≤II, thereby improving the probability of neurologic recovery. Therefore, current data support expedited surgery in patients with progressive neurologic deficit at the time of presentation.

The decision about the timing of surgery must be made after careful consideration of modifiable risk factors. The level of urgency of surgery is determined by the speed of neurologic deficit progression, the severity of deficit and the duration of deficit before presentation to medical attention. Currently available data fail to provide clear information about the hourly or even daily incremental effect on the neurologic recovery. Furthermore, survey of AOSpine Knowledge Forum Tumor members showed lack of consensus about any time points that would disqualify patients from surgery or that serve as concrete adverse indicators of recovery. Therefore, the urgency of surgical decompression must be weighed against the need to minimize the risk of perioperative morbidity and the decision about the timing of surgery must be made after consideration of individual and situation-specific safety and efficacy considerations. In patients at high risk of perioperative complication, palliative nonsurgical interventions should be carefully considered.

Surgical decision-making requires clear understanding of tumor biology. We must emphasize that the recommendations presented in the current review apply to solid tumor metastases and exclude tumors with high sensitivity to radiation therapy. Hematologic malignancies such as lymphoma and multiple myeloma and other exquisitely radiosensitive tumors such as small cell variants and seminomas rapidly decrease in volume after radiotherapy and generally do not require surgical decompression even in the setting of symptomatic MESCC. Among patients presenting with MESCC owing to a tumor of unknown histology, neurologic preservation takes precedence over diagnosis, with surgical spinal cord decompression justified to halt progression of an evolving neurologic deficit and to shorten the duration of the deficit.

Survey of AOSpine Knowledge Forum Tumor members revealed that the majority of respondents considered incomplete neurologic recovery, such as independent ambulation with or without walking aids, or muscle strength improvement or intact bladder function without ambulation restoration as adequate goals of surgery for patients presenting with neurologic deficits owing to MESCC. Therefore, although the current expert opinion suggests a fairly low threshold for justification of surgical intervention, the definition of favorable postoperative outcome requires patient-specific adjustment based on patient expectations, needs, and overall medical condition.

Low- to very-low-quality evidence supports consideration of the presence of VCF, level of spinal cord compression, previous radiation history, Tokuhashi score, and prostate-specific factors in prediction of postoperative neurologic deficit improvement. The predictive value of these variables is unclear at this time and current data do not support their utility in surgical decision-making.

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Limitations

Publications describing treatment outcomes in patients with MESCC employ heterogeneous methods of reporting of neurologic function and ambulation and the variability of outcome reporting confounds the ability to pool and compare results of these studies. Additionally, the timing of the postoperative assessment and the type of surgery conducted varied, further complicating combined interpretation of the data. Publication bias cannot be excluded as an additional limitation. Finally, we should not assume that the studies included in the current review exhausted the list of possible variables associated with neurologic recovery. For example, it has been postulated that the speed of deficit progression may serve as a predictor of neurologic recovery; however, currently available studies lack information about this variable. Future investigation should focus on finding new ways to predict and optimize neurologic recovery in patients with MESCC. The results of the current literature review and the survey provide guidance about the data points that should be included in future studies.

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RECOMMENDATION

A patient who is experiencing neurologic deficit from solid tumor MESCC resulting in loss of ability to ambulate, in the absence of medical and oncologic contraindications, requires urgent surgical decompression. Expeditious diagnosis and prompt surgery are recommended to improve the probability of neurologic recovery.

Strength of Recommendation: Strong

Quality of Evidence: Low

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CONCLUSIONS

In patients with metastatic spine disease-causing neurological impairment, the duration and severity of neurologic deficit serve as prognostic indicators for neurological recovery after surgery. Longer duration of preoperative deficit results in lower probability of neurological improvement. Patients with preserved bladder function and MRC grade ≥III preoperatively are have a higher probability of neurologic improvement. Effort should be made to shorten the duration of neurologic deficit and to prevent further neurologic deterioration. The decision about the timing of surgery must be made after consideration of modifiable risks of surgical morbidity. Clear predictive models with consideration of duration and severity of preoperative neurologic deficit are required to guide clinical practice and facilitate treatment decisions for patients with MESCC.

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References

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12. Furstenberg CH, Wiedenhofer B, Gerner HJ, et al. The effect of early surgical treatment on recovery in patients with metastatic compression of the spinal cord. J Bone Joint Surg Br 2009; 91:240–244.
13. Crnalic S, Hildingsson C, Bergh A, et al. Early diagnosis and treatment is crucial for neurological recovery after surgery for metastatic spinal cord compression in prostate cancer. Acta Oncol 2013; 52:809–815.
14. Quraishi NA, Rajagopal TS, Manoharan SR, et al. Effect of timing of surgery on neurological outcome and survival in metastatic spinal cord compression. Eur Spine J 2013; 22:1383–1388.
15. Hessler C, Burkhardt T, Raimund F, et al. Dynamics of neurological deficit after surgical decompression of symptomatic vertebral metastases. Spine 2009; 34:566–571.
16. Park JH, Jeon SR. Pre- and postoperative lower extremity motor power and ambulatory status of patients with spinal cord compression due to a metastatic spinal tumor. Spine (Phila Pa 1976) 2013; 38:E798–802.
17. Chaichana KL, Pendleton C, Wolinsky JP, et al. Vertebral compression fractures in patients presenting with metastatic epidural spinal cord compression. Neurosurgery 2009; 65:267–274.discussion 74-5.
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Keywords:

ambulation; bladder; MESCC; metastasis; neurologic outcome; prognosis; recovery; spinal cord compression; spine; surgery; systematic review; tumor

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