Complication rates in the literature are difficult to categorize due to variations in definitions and reporting. However, broadly speaking, overall complication rates following XLIF have been generally reported in the range of 2%36 to 30.4%42 (with an outlier of 150%,41 see Discussion); described as minor in up to 20%,31 and major in up to 8.6%.33 The most common reported complaint was postoperative thigh symptoms, at a rate of 136,37 to 60.1%,30 described as transient, generally resolving within weeks following surgery.
Literature-reported improvements in patient-reported clinical outcome scores include ranges of 32.4%29 to 80%39 decrease in VAS and 39%35 to 82.1%30 decrease in ODI. Literature-reported fusion rates following XLIF are reported in ranges from 91%35 to 100%.30,34,42 The results of the current retrospective cohort fall within these ranges for all measures.
The lateral approach to the anterior column of the lumbar spine is not new, but had in fact been defined in the historical literature as an alternative to direct anterior approaches.44–53 There have been several anatomic descriptions of the retroperitoneum, the psoas muscle, and the lumbar plexus within it.54–59 There have also been several reports that detail the surgical technique and/or case reports.28,60–67 The results presented herein, however, were restricted to those from published reports inclusive of safety and/or effectiveness outcomes. The 14 articles reviewed ranged in application, but were largely reports of the use of the lateral approach to interbody fusion for the treatment of multiple degenerative conditions.
Reviewing each study from a chronological perspective, and first with respect to nondeformity degenerative conditions, Rodgers et al36 reported on the early results of 100 patients having undergone XLIF for multiple degenerative conditions in 2007. As one of the earliest reports with clinical outcomes, it described the procedure as safe and reproducible, with a low complication rate (2%), short hospital stays (average, 1.5 days), and good improvement in clinical and radiographic outcomes (reduction in VAS pain scores of 68.7%; significant correction of disc height, sagittal and coronal alignment out to 6 months).
In 2009, Knight et al33 reported on the results of 58 lateral approach surgeries using combined techniques for multiple degenerative conditions. They reported relatively long operative times (mean, 161 minutes; range, 75–445 minutes), higher blood loss (range, 25–600 mL), and long hospital stays (average, 5 days) compared with other lateral approach reports described for similar nondeformity cases, their results raising questions about technique and learning curve (58 patients across 4 operating surgeons). The authors described a 22.4% overall complication rate, half of which (11.2%) were described as approach-related. Six patients (10.3%) complained of psoas muscle spasm due to the approach, which was not considered a complication; postoperative hip flexion and gentle range of motion exercises were recommended. Six patients (10.3%) experienced sensory leg symptoms that the authors described as meralgia paresthetica. Two patients (3.4%) experienced a motor nerve injury, which improved over time but were residually lasting at 1 year postoperative and were considered major complications. Other major complications included myocardial infarction, subsidence (of a cylindrical cage) and loss of correction requiring reoperation. Although there was an average 15-month follow-up, the authors did not report clinical or radiographic results. They concluded that, overall, morbidity was lower than in traditional open procedures, and that the minimally invasive lateral approach is a valuable treatment option in this patient population.
Also in 2009, Rodgers et al37 reported on the results of 100 patients having undergone XLIF specifically for adjacent level degeneration, that is, degenerative conditions adjacent to prior fusion surgery. The authors described the lateral approach as a good alternative to having to approach the spine through prior anterior or posterior scar tissue and revise prior instrumentation. Again recovery was reported as quick, with average 1.13 days hospital stay, low overall complication rate (9%), 1% transient thigh symptoms, and significant improvements in pain scores (67.4%) and radiographic measures, including satisfactory progression toward fusion, at least in the 6-month follow-up period.
In 2010, many more reports of outcomes following lateral approach surgery became available, with more focus on mid- to long-term results. Oliveira et al34 reported the fusion rates of 15 stand-alone XLIF procedures using BMP. Although this study was a small patient-series, it was prospectively collected, and evaluated critically using CT studies. The authors described short operative time (67 minutes), low blood loss (average, 50 mL), minor complications (6.7%), and short hospital stay (12–48 hours). Patients experienced a statistically significant improvement in pain and function scales at all postoperative visits. Two patients required reoperation; 1 for additional direct posterior decompression, 1 to correct heterotopic bone formation creating foraminal stenosis. Radiographically, all patients demonstrated fusion on CT scan at last follow-up. Implant subsidence occurred in 1 patient (6.7%), but did not affect clinical or fusion outcome.
Rodgers et al38 reported on a series of more than 300 XLIF patients, categorized in about equal numbers as obese and nonobese. In this comparative analysis, the authors were able to conclude that their minimal morbidity results were not statistically affected by body habitus, and that the lateral approach is a good alternative to traditional open anterior and posterior approaches in the obese, which can be technically difficult and have been shown to result in higher incidences of infection and other complications. The same authors later reported on fusion rates following XLIF surgery.39 Using CT evaluations at a minimum 12-month follow-up, 85/88 levels (96.6%) in 64/66 patients (97.0%) were fused, and the authors stated that no revisions for pseudarthrosis occurred. Clinical outcome scores were not reported, but patient satisfaction was high at 89.4%.
One of the first articles to address the application of lateral approach surgery in deformity was that by Anand et al,29 who reported on an early experience of 12 patients having undergone combined minimally invasive procedures, inclusive of lateral interbody fusion, for the treatment of adult scoliosis. Compared with prior reports, these were more complex pathologies requiring more complex procedures, but nevertheless resulted in low blood loss (average, 164 mL) compared with traditional scoliosis surgery. They reported good early pain reduction (32.4%), despite 3 of the 12 patients (25%) having what was described as dysesthesia and another with transient quadriceps weakness following surgery, both resolving within 6 weeks. This study was limited by short follow-up (average, 75 days).
The study by Ozgur et al35 in 2010 was in a patient population with a combination of degenerative conditions, much of it adult scoliosis, with treatment including procedures up to 5 levels. In 62 patients/113 levels with 2-year follow-up, there were no major and 19% minor complications, including 3 wound events, 3 respiratory events, 2 cardiovascular events, 2 ileus, and 1 pseudarthrosis. They described transient hip flexion weakness and upper thigh numbness as a common consequence of the approach, generally resolved within 6 weeks. Pain and function improvements were maintained at 2 years and fusion was described as radiographically evident in 91% of patients.
Indeed, reported results inclusive of adult scoliosis populations have been more variable, which is not surprising, given both the multilevel nature of the pathology, as well as generally confounding demographic variables such as increased age and pre-existing age-related comorbidities. Anand et al30 followed his 2008 report with another in 2010 on 28 patients with a mean follow-up of 22 months. They reiterated similar operative times and blood loss to their prior report, and further defined mid- to long-term results as positive, with significant improvements in VAS pain (57%) and ODI functional outcome (82.1%) scores. They reported that all patients (100%) maintained correction of their deformity and were noted to have solid fusion on plain radiographs. They concluded that the minimally invasive approach may be particularly useful in the elderly given the demonstrated decrease in postoperative morbidity compared with traditional open procedures for deformity correction. Dakwar et al31 reported similar results in a series of 25 adult deformity patients with mean 11-month follow-up. Despite the multilevel procedural requirements, operative time was short (average, 108 minutes), blood loss minimal (average, 53 mL), with mostly minor complications (20%, 4% major). Of the patients, 12% had what was described as transient postoperative anterior thigh numbness. Clinical outcomes reported included 70.4% and 44.2% improvement in pain (VAS) and function (ODI), respectively. Of the 25 patients, 20 had minimum 6-month follow-up, and all of these (100%) were reported to have demonstrated radiographic fusion on CT scan or flexion/extension radiographs.
In the same journal issue, Wang and Mummaneni42 reported on 23 adult scoliosis patients who underwent lateral approach surgery with some variation to the technique described by Pimenta and others as XLIF. Procedures included interbody fusion at up to 5 levels, with bilateral posterior pedicular fixation, and the use of BMP in the interspace. Reported operative times were long (average, 477 minutes) and blood loss was higher than generally reported (average, 401 mL). They reported no intraoperative complications, but transient thigh symptoms occurred in 7 of the 23 patients (30.4%). Pain was significantly improved at a mean follow-up of 12 months, and radiographic corrections included an average 20 degree improvement in coronal alignment, and an average 8 degree improvement in overall thoracolumbar lordosis. All interbody levels (100%) were identified as fused by CT evaluation.
Tormenti et al41 reported a series of 8 adult scoliosis patients having undergone a lateral-approach procedure with posterior instrumented fusion, in comparison with 4 patients having undergone posterior-approach instrumented fusion procedures (PLIF or TLIF). The study showed significant coronal curve correction capabilities using the lateral approach (70.2%, compared with 44.7% correction using a posterior-only approach); and all patients had normal lumbar lordosis after surgery. However, significant complications were reported, including bowel perforation, infection, sensory and motor disturbances, pleural effusion, hemodynamic instability, pulmonary embolism, ileus, and durotomy (during posterior instrumentation). Of the 8 patients, 6 (75%) were described as having experienced postoperative thigh paresthesias or dysesthesias. Two patients (25%) had motor neural deficits, one of which resolved after 2 months, the other persistent at last follow-up of 3 months. There were no instrumentation failures or pseudarthrosis at the last follow-up, which was an average of 11 months postoperative. Pain scores were significantly improved. Despite a high complication rate compared with other literature reports, the authors conclude that the lateral approach may provide a good alternative to traditional posterior approaches, given the low blood loss and increased correction capabilities. They go on to explain their single incident of bowel perforation as potentially a factor of a rotatory component of scoliosis deformity, as they had not encountered this problem in their nondeformity lateral approach experience. One would indeed have to consider whether the higher-than-normal complication rates in this study are reflective of the technique, experience, or particular patient cohort. As a series of only a very small number of patients (n = 8), it is arguably an outlier in this review, but was included to demonstrate the potential risks, and contrast those with the generally positive results reported in larger series with longer experience.
The largest series to date has been that by Rodgers et al,40 who reported on the complication profile following XLIF surgery in 600 patients and 741 levels. Perioperative complications (out to 6 weeks) occurred in 6.2% of patients, and included 9 (1.5%) in-hospital surgery-related events, 17 (2.8%) in-hospital medical events, 6 (1.0%) out-of hospital surgery-related events, and 5 (0.8%) out-of-hospital medical events. There were no wound infections, no vascular injuries, no intraoperative visceral injuries, and 4 (0.7%) transient postoperative neurologic deficits. Eleven events (1.8%) resulted in additional procedures or reoperation.
Finally, in an editorial on the value and cost of minimally invasive procedures, Deluzio et al32 provide the results of a controlled cost comparison between open 2-level PLIF procedures and minimally invasive 2-level XLIF procedures, and showed a cost savings of nearly 10% or $2500 per patient in the perioperative period, largely defined by decreased hospital stay and what are described as residual care events after surgery, such as intensive care unit usage, physical therapy, emergency room visits, etc.
Overall, the lateral approach to anterior column reconstruction appears to have some advantages compared with traditional anterior and posterior approaches to the lumbar spine: the XLIF approach does not require a general access surgeon, does not retract or violate the peritoneum, eliminates the need for mobilization of the great vessels and preserves the anterior and posterior longitudinal ligaments. The lateral approach is susceptible to risks similar to any spine surgery, but the incidence of these events is reportedly low and within the acceptable range of literature-reported complications following traditional spine surgical procedures.12,13,15,22,23,68–75 In fact, some of these risks such as postoperative medical issues and infection appear to be minimized with the use of a minimally invasive procedure compared with traditional open procedures,20 presumably due to the use of smaller incisions and minimal disruption of surrounding anatomy. The most common complaint following XLIF appears to be thigh weakness and/or numbness, perhaps as a consequence of trauma to the psoas muscle during the approach. The literature suggests that this is largely transient, and recovers with soft-tissue healing following surgery, akin to paraspinal muscle weakness following posterior approach surgery. However, in a reported small percentage of patients, neurogenic motor, and/or sensory deficits may occur. The reported rates of specific neural injury are within the range of those following traditional direct anterior approaches,73,74 and lower than those following traditional posterior approaches.13,15,43–45
Proper surgeon training is required to ensure the reduction of complications related to a lateral-approach procedure. Knowledge of the relevant anatomy and appropriate positioning of a patient is necessary for a successful procedure. The use of real-time, dynamic, and discrete neurologic monitoring during the entire procedure can lead to the protection of the lumbar plexus. Preoperative review of the axial MRI/CT images will allow the surgeon to confirm that abdominal vessels do not obstruct the lateral disc space, observe neural structures at the operative level(s), and identify that the pelvis does not obstruct access to the operative level. The use of fluoroscopic visualization during the procedure can assist a surgeon in avoiding endplate violation during discectomy and implant insertion by confirming direct lateral access to the disc space throughout.
The current cohort analysis corroborates prior reports, which together suggest that XLIF is a viable procedure option for the treatment of degenerative conditions, with minimal operative time, blood loss, and recovery, as well as demonstrated clinical, radiographic, and cost effectiveness.
Further published literature is warranted in support of XLIF in comparison to the traditional lumber interbody fusion approaches. We anticipate reporting on final radiographic and clinical outcome data when all patients achieve longer follow-up.
- The current study results corroborate and contribute to the existing literature with respect to minimal morbidity, as shown by perioperative outcomes; safety, as shown by complication rates; and effectiveness, as shown by fusion rates.
- Postoperative thigh symptoms seem to be the most common complaint, but literature suggests that they are transient and may be outweighed by the significant improvements in pain and function with the minimal morbidity advantages of the minimally invasive procedure.
- Long-term outcomes of extreme lateral interbody fusion are generally favorable, with maintained improvements in patient-reported pain and function scores as well as radiographic parameters, including high rates of fusion.
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Keywords:© 2010 Lippincott Williams & Wilkins, Inc.
XLIF; anterior lumbar interbody fusion; ALIF; MIS; clinical outcomes