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Spine Update: Prevention of Postoperative Infection in Patients Undergoing Spinal Surgery

Brown, Erwin M. FRCPath*; Pople, Ian K. FRCS; de Louvois, John FRCPath; Hedges, Alan PhD§; Bayston, Roger FRCPath; Eisenstein, Stephen M. FRCS||; Lees, Peter FRCS##for the British Society for Antimicrobial Chemotherapy Working Party on Neurosurgical Infections

Spine Update

The British Society for Antimicrobial Chemotherapy Working Party on Neurosurgical Infections evaluated published evidence for the efficacy of antimicrobial prophylaxis in patients undergoing spinal surgery. The conclusions are reported, and recommendations for the prevention of surgical site infections in general and discitis in patients undergoing procedures that violate one or more discs are provided. The roles of intraoper-ative antibiotic or antiseptic wound irrigation and drains are also reviewed.

From the Departments of *Medical Microbiology and †Neurosurgery, Frenchay Hospital, Bristol, U.K.; ‡Public Health Laboratory Service, London, U.K.; §Department of Pathology and Microbiology, University of Bristol, Bristol, U.K.; ¶Department of Orthopaedic Surgery, Queen's Medical Centre, Nottingham, U.K.; ||Centre for Spinal Studies, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, U.K.; and #Department of Neurosurgery, Southampton General Hospital, Southampton, U.K.

Acknowledgment date: December 4, 2002. First revision date: April 3, 2003. Acceptance date: October 21, 2003.

Funding for the Working Party was provided by the British Society for Antimicrobial Chemotherapy.

The device(s)/drug(s) that is/are the subject of this manuscript is/are not FDA-approved for this indication and is/are not commercially available in the United States.

Professional organization funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

Address correspondence to Erwin M. Brown, Department of Medical Microbiology, Frenchay Hospital, Bristol, BS16 1LE, U.K.; E-mail:

© 2004 Lippincott Williams & Wilkins, Inc.