aSpine Care Institute, Hospital for Special Surgery, New York, NY
bDepartment of Orthopaedic Surgery, School of Medicine, Showa University Hospital, Tokyo, Japan
cWeill Cornell Medicine, New York, NY
The work was performed at Hospital for Special Surgery, New York, NY.
The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and approved by the Institutional Review Board of the Hospital for Special Surgery.
Y.D., I.O., J.S., and A.A.S. conceived and designed the study; all authors participated in the planning, conduct, reporting, and interpretation of data. Y.D., I.O., H.H., M.M., L.O., J.S., N.A.K., and L.A.S. participated in acquisition of data. I.O. performed statistical analysis. Y.D. wrote the manuscript; all authors participated in revising the manuscript. Y.D., I.O., and A.A.S. accepts full responsibility for the work and conduct of this study, had access to the data, and controlled the decision to publish.
A.A.S. reports royalties from Ortho Development Corp.; private investments for Vestia Ventures MiRUS Investment LLC, ISPH II LLC, ISPH 3 LLC, and VBros Venture Partners X Centinel Spine; consulting fee from Clariance Inc., Kuros Biosciences AG, and Medical Device Business Service Inc.; speaking and teaching arrangements of DePuy Synthes Products Inc.; membership of the scientific advisory board of Clariance Inc., and Kuros Biosciences AG; and trips/travel of Medical Device Business research support from Spinal Kinetics Inc., outside the submitted work. F.P.C. reports royalties from NuVasive Inc.; private investments for 4WEB Medical/4WEB Inc., Accelus, Bonovo Orthopedics Inc., Healthpoint Capital Partners, LP, ISPH II LLC, ISPH 3 Holdings LLC, Ivy Healthcare Capital Partners LLC, Medical Device Partners II LLC, Medical Device Partners III LLC, Orthobond Corporation, Spine Biopharma LLC, Synexis LLC, Tissue Differentiation Intelligence LLC, VBVP VI LLC, VBVP X LLC (Centinel) and Woven Orthopedics Technologies; consulting fees from 4WEB Medical/4WEB Inc., DePuy Synthes Spine, NuVasive Inc., Spine Biopharma LLC, and Synexis LLC; membership of scientific advisory board/other office of Healthpoint Capital Partners, LP, Medical Device Partners III LLC, Orthobond Corporation, Spine Biopharma LLC, Synexis LLC, and Woven Orthopedic Technologies; and research support from 4WEB Medical/4WEB Inc., Mallinckrodt Pharmaceuticals, Camber Spine, and Centinel Spine, outside the submitted work. F.P.G. reports royalties from Lanx Inc., and Ortho Development Corp.; private investments for Centinel Spine, and BCMID; stock ownership of Healthpoint Capital Partners, LP; and consulting fees from NuVasive Inc., and DePuy Synthes Spine, outside the submitted work. A.P.H. reports research support from NuVasive Inc. and Kuros Biosciences AG; and fellowship support from NuVasive Inc. and Kuros Biosciences AG, outside the submitted work. D.R.L. reports royalties from NuVasive Inc. and Stryker; private investments from HS2 LLC, Woven Orthopedic Technologies, Vestia Ventures MiRus Investiment LLC, ISPH LLC; consulting fee from Depuy Synthes, Vizeon Inc.; scientific advisory board from Remedy Logic; and research support from Medtronic. The remaining authors report no conflicts of interest.
Address correspondence and reprint requests to Andrew A. Sama, MD, Spine Care Institute, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021; E-mail: [email protected]