Retrospective review of a prospective database.
The aim of this study was to evaluate postop clinical recovery among adult spinal deformity
) patients between frailty
states undergoing primary procedures
Summary of Background Data. Frailty
severity may be an important determinant for impaired recovery after corrective surgery.
It included ASD
patients with health-related quality of life (HRQLs) at baseline (BL), 1 year (1Y), and 3 years (3Y). Patients stratified by frailty
index scale 0-1(no frailty
: <0.3 [NF], mild: 0.3–0.5 [MF], severe: >0.5 [SF]). Demographics, alignment, and SRS-Schwab modifiers were assessed with χ2
tests to compare HRQLs: Scoliosis Research Society 22-question Questionnaire (SRS-22), Numeric Rating Scale (NRS) Back/Leg Pain, Oswestry Disability Index (ODI). Area-under-the-curve (AUC
) method generated normalized HRQL scores at baseline (BL) and f/u intervals (1Y, 3Y). AUC
was calculated for each f/u, and total area was divided by cumulative f/u, generating one number describing recovery (Integrated Health State [IHS]).
A total of 191 patients were included (59 years, 80% females). Breakdown of patients by frailty
status: 43.6% NF, 40.8% MF, 15.6% SF. SF patients were older (P
= 0.003), >body mass index (P
= 0.002). MF and SF were significantly (P
< 0.001) more malaligned at BL: pelvic tilt (NF: 21.6°; MF: 27.3°; SF: 22.1°), pelvic incidence and lumbar lordosis (7.4°, 21.2°, 19.7°), sagittal vertical axis (31 mm, 87 mm, 82 mm). By SRS-Schwab, NF were mostly minor (40%), and MF and SF markedly deformed (64%, 57%). Frailty
groups exhibited BL to 3Y improvement in SRS-22, ODI, NRS Back/Leg (P
< 0.001). After HRQL normalization, SF had improvement in SRS-22 at year 1 and year 3 (P
< 0.001), and NRS Back at 1Y. 3Y IHS showed a significant difference in SRS-22 (NF: 1.2 vs.
MF: 1.32 vs.
SF: 1.69, P
< 0.001) and NRS Back Pain (NF: 0.52, MF: 0.66, SF: 0.6, P
= 0.025) between frailty
groups. SF had more complications (79%). SF/marked deformity had larger invasiveness score (112) compared to MF/moderate deformity (86.2). Controlling for baseline deformity and invasiveness, SF showed more improvement in SRS-22 IHS (NF: 1.21, MF: 1.32, SF: 1.66, P
Although all frailty
groups exhibited improved postop disability/pain scores, SF patients recovered better in SRS-22 and NRS Back. Despite SF patients having more complications and larger invasiveness scores, they had overall better patient-reported outcomes, signifying that with frailty
severity, patients have more room for improvement postop compared to BL quality of life.
Level of Evidence: 3