Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Effects of Athermal Shortwave Diathermy Treatment on Somatosensory Evoked Potentials and Motor Evoked Potentials in Rats With Spinal Cord Injury

Xie, Caizhong PhD; Li, Xiangzhe MD†,‡; Fang, Lu MD§; Wang, Tong PhD§

doi: 10.1097/BRS.0000000000002980
BASIC SCIENCE
Buy
SLIDE

Study Design. A study on shortwave diathermy (SWD) versus no treatment following induced spinal cord injury (SCI) in rats.

Objective. To investigate the effects of athermal SWD treatment on somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) and hindlimb movements in rats with SCI.

Summary of Background Data. SWD has been proven to improve vascular circulation and reduce inflammation. However, there have been few studies on neuroprotective effect of SWD on SCI.

Methods. Twenty-four female Sprague–Dawley (SD) rats were randomly divided into four groups: sham, SCI, SWD, and intact groups. The SCI model was established using the modified Allen weight-drop method. The SWD group received 15 sessions of athermal SWD treatment over a 3-week period of time at 24 hours after SCI. While the sham group and SCI group received no treatment after surgery. Hindlimb movements were evaluated by the Basso, Beattie, and Bresnahan (BBB) scale before surgery, and on days 1, 7, 14, and 21 after the surgery, respectively. The SEP and MEP measurements were simultaneously performed to detect the responses of neural conduction.

Results. The week-by-week BBB scores showed a gradual improvement in the rats of both SCI and SWD groups from the first week to the end of the study; however, the BBB scores of the SWD group were higher than those of the SCI group over the course of 3 weeks. Data from the SEP and MEP measurements showed a significant improvement in the SWD group compared with the SCI group at each time point of observation, with a more prominent increase of amplitude and a more evident reduction of latency. There was a linear correlation between the BBB scores and the latency and amplitude of SEPs or MEPs.

Conclusion. Athermal SWD treatment might facilitate the recovery of locomotor function and exert neuroprotective effect on the SCI.

Level of Evidence: N/A

We have explored the effects of athermal shortwave diathermy (SWD) in spinal cord injury (SCI). Sprague–Dawley rats received athermal SWD treatment at 24 hours after SCI. The Basso, Beattie, and Bresnahan scales and somatosensory evoked potentials and motor evoked potentials were used to measure changes of neurological function. Our results showed that athermal SWD treatment exerts neuroprotective effect in SCI.

Department of Rehabilitation Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, China

Rehabilitation Medicine Center of Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, China

Rehabilitation Medicine Center of Suzhou Science & Technology Town Hospital, Suzhou, Jiangsu Province, China

§Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Address correspondence and reprint requests to Tong Wang, PhD, Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; E-mail: wangtong60621@163.com; Caizhong Xie, PhD, Department of Rehabilitation Medicine, Jinling Hospital of Nanjing Medical University, 305 East Zhongshan Road, 210002, Nanjing, China; E-mail: xczh300@sina.com

Received 11 May, 2018

Revised 19 July, 2018

Accepted 18 September, 2018

The manuscript submitted does not contain information about medical device(s)/drug(s).

The National Natural Science Foundation of China (8117185) grant funds were received in support of this work.

No relevant financial activities outside the submitted work.

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.