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Validity of Transcranial Motor Evoked Potentials as Early Indicators of Neural Compromise in Rat Model of Spinal Cord Compression

Morris, Susan H., PhD*,†; Howard, Jason J., MD; Rasmusson, Douglas D., PhD§; El-Hawary, Ron, MD*,†

doi: 10.1097/BRS.0000000000000808
Diagnostics
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Study Design. Randomized controlled study of intraoperative transcranial motor evoked potentials (TcMEPs) as early indicators of neural compromise in a rat model of spinal cord compression.

Objective. To determine the temporal threshold at which a complete (100%) loss of intraoperative TcMEPs will result in significant postoperative functional deficits.

Summary of Background Data. There is controversy about the best TcMEP alarm criteria for intraoperative spinal cord protection. Clinical trials provide some evidence, but randomized controlled trials, which are not feasible in humans, are lacking.

Methods. Twenty-four adult male Wistar rats were divided into 3 experimental groups according to the length of time that a 100% TcMEP signal loss was maintained; all animals had preoperative functional testing. After surgical placement of a balloon catheter in the thoracic sublaminar space, TcMEPs were recorded while the spinal cord was compressed by balloon inflation. The recordings were terminated after maintaining a 100% TcMEP loss for different time periods (0, 5, or 15 min). Functional behavioral testing was repeated after 24 hours.

Results. Only the groups wherein the catheter was left inflated for 5 or 15 minutes after a complete (100%) loss of TcMEP amplitude showed a significant deterioration in functional testing as compared with preoperative baseline values. Functional testing remained normal for both the control group and the group in which termination of spinal cord compression occurred immediately after a decrease of TcMEP amplitude to 100%. There was a strong correlation between TcMEP amplitude recovery postintervention and functional ability at 24 hours postsurgery.

Conclusion. If a 100% loss of TcMEP signals is immediately recognized and reversed by rapid removal of the compressive force on the spinal cord, normal postoperative function was observed in this rat model. However, delaying intervention for even 5 minutes can result in significant postoperative functional deficits.

Level of Evidence: N/A

Adult rats were randomized into 3 experimental groups based on how long spinal cord compression was held (0, 5, or 15 min) after a complete transcranial motor evoked potential (TcMEP) loss; pre- and postoperative functional testing was done. A complete TcMEP loss was tolerated if the cause was reversed immediately. Delaying intervention could cause functional deficits.

*IWK Health Centre, Halifax, Nova Scotia, Canada

Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada

Division of Paediatric Orthopaedics, Sidra Medical and Research Center, Doha, Qatar; and

§Department of Physiology & Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.

Address correspondence and reprint requests to Susan H. Morris, PhD, IWK Health Centre, 5850 University Ave, PO Box 9700, Halifax, Nova Scotia, Canada B3K 6R8; E-mail: susan.morris2@iwk.nshealth.ca

Acknowledgment date: April 29, 2014. First revision date: December 1, 2014. Second revision date: January 14, 2015. Acceptance date: January 22, 2015.

The manuscript submitted does not contain information about medical device(s)/drug(s).

The Pediatric Orthopaedic Society of North America grant funds were received in support of this work.

Relevant financial activities outside the submitted work: board membership, consultancy, grants, payment for lectures.

Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.