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Bone Marrow Concentrate With Allograft Equivalent to Autograft in Lumbar Fusions

Johnson, Robert G. MD

doi: 10.1097/BRS.0000000000000254
Randomized Trial

Study Design. Prospective randomized study.

Objective. To compare autologous bone marrow concentrate mixed with allograft cancellous bone to iliac crest autograft in lumbar fusions.

Summary of Background Data. Bone marrow has been shown to be a rich source of osteoprogenitor cells. Osteoprogenitor cells have been shown in animals, and some human studies, to have potential in use as a bone graft substitute.

Methods. Twenty-five patients underwent from 1- to 3-level lumbar fusions. One patient was lost to follow-up. On one half of the spine, allograft plus autologous bone marrow concentrate was used, whereas on the other half, autologous iliac crest bone was used. Cellular analysis, consisting of nucleated cell count, mononuclear cell count, CD34+ count, and colony-forming-units-fibroblast count, was done on marrow aspirates and concentrates. At 1 year postoperation, computed tomographic scans of the fusions were evaluated on a blinded basis by 2 neuroradiologists independent of each other. Radiographical fusion was the primary outcome measure.

Results. There was no statistical difference in fusion scores between allograft and autograft in the lateral gutters, interbody cages, or facet joints. There was a positive trend between CD34+ counts and radiographical fusion.

Conclusion. The study shows equivalence between cancellous allograft mixed with bone marrow concentrate and autologous iliac crest bone for lumbar fusions.

Level of Evidence: 2

A prospective randomized lumbar fusion study comparing the use of autologous bone marrow concentrate mixed with allograft cancellous bone versus iliac crest autograft. The study showed equivalence between bone marrow concentrate with cancellous allograft and autograft for lumbar fusions after 1 year.

From the Neurosurgical Associates of San Antonio, San Antonio, TX.

Address correspondence and reprint requests to Robert G. Johnson, MD, Neurosurgical Associates of San Antonio, 4410 Medical Dr, #610, San Antonio, TX, 78229; E-mail:

Acknowledgment date: August 21, 2012. Revision date: November 27, 2013. Acceptance date: January 21, 2014.

The device(s)/drug(s) is/are FDA approved or approved by corresponding national agency for this indication.

No funds were received in support of this work.

Relevant financial activities outside the submitted work: royalties, stocks.

© 2014 by Lippincott Williams & Wilkins