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ISSLS Prize Winner: An In Vivo, Multimodal, Prospective Study of 181 Subjects

Rajasekaran, S., PhD, MS, MCh, FRCS(Ed), FRCS(London), FACS; Bajaj, Nipun, MS, FNB; Tubaki, Vijay, MS; Kanna, Rishi M., MS, MRCS, FNB; Shetty, Ajoy Prasad, MS, DNB

doi: 10.1097/BRS.0b013e31829a6fa6
Diagnostics
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Study Design. A prospective multimodal study including clinical, radiological, serial postcontrast magnetic resonance imaging, intraoperative findings, and histopathological study.

Objective. To document in vivo, the site of anatomical failure in lumbar disc herniation (LDH).

Summary of Background Data. Although in vitro mechanical disruption studies have implicated both the endplate junction (EPJ) and the annulus fibrosus (AF) as the site of failure in LDH, there are no in vivo human studies to document the exact anatomy of failure.

Methods. One hundred eighty-one consecutive patients requiring microdiscectomy at a single level formed the study group. The status of the endplate and AF in the operated level (study discs) and the other discs (control) were evaluated by plain radiograph, thin slice computed tomographic scan, plain and contrast magnetic resonance imaging, intraoperative examination, and histopathological analysis.

Results. LDH due to EPJ failure (EPJF- type I herniation) was more common (117; 65%) than annulus fibrosis rupture. Herniated discs had a significantly higher incidence of EPJF than control discs (P < 0.0001). The EPJF was evident radiologically as vertebral corner defect in 30 patients, rim avulsion in 46, frank bony avulsions in 24, and avulsion at both upper and lower EP in 4. Thirteen discs with normal EP radiologically had cartilage or bone avulsion intraoperatively. Sixty-four discs (35%) had intact EP of which annular high intensity zone was found in 21 (11%), suggesting a disruption of AF (type II herniation). Postcontrast magnetic resonance image of 20 patients showed dye leak at the EPJ proving EPJF as main cause of LDH.

Conclusion. Our study provides the first in vivo evidence that LDH in humans is more commonly the result of EPJF than AF rupture and offers clinical validation of previous in vitro mechanical disruption studies. Future research must focus on the EPJ as a primary area of interest in LDH.

Level of Evidence: N/A

A multimodal prospective study in 181 consecutive patients with lumbar disc herniation proved that endplate avulsion and not annulus fibrosus rupture was the most common mode of disc failure. Future research must focus on endplate as the area of primary interest in disc herniation

From the Department of Orthopaedics and Spine Surgery, Ganga Hospital, Coimbatore, Tamil Nadu, India.

Address correspondence and reprint requests to S. Rajasekaran, PhD, MS, MCh, FRCS(Ed), FRCS(London), FACS, Department of Orthopaedics and Spine Surgery, Ganga Hospital, 313, Mettupalayam Road, Coimbatore - 641043, Tamil Nadu, India; E-mail: sr@gangahospital.com

Acknowledgment date: October 16, 2012. First revision date: December 25, 2012. Second revision date: February 11, 2013. Acceptance date: February 14, 2013.

The manuscript submitted does not contain information about medical device(s)/drug(s).

Ganga Orthopaedic Research and Education Foundation grant funds were received in support of this work.

No relevant financial activities outside the submitted work.

© 2013 by Lippincott Williams & Wilkins