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Multifocal Osteolytic Lesions Within Lumbar Spine in a Middle-Aged Chinese Woman: A Benign Metastasizing Leiomyoma?

Wang, Li-xun PhD; Lv, Fei-zhou PhD; Ma, Xin PhD; Jiang, Jian-yuan MD

doi: 10.1097/BRS.0b013e31822e9578
Case Report

Study Design. Case report.

Objective. To describe a case presented as osteolytic lesions involving 2 inconsecutive lumbar, which was pathologically proved to be of smooth muscular origin.

Summary of Background Data. Smooth muscle tumor of uncertain malignant potential (STUMP) could be diagnosed when the neoplasm showed some malignant behavior, whereas its histologic image revealed very low malignance. A 47-year-old woman presented with low back pain and numbness of the left lower extremity attributable to osteolytic lesions in the second and fourth lumbar vertebral bodies, which was subsequently diagnosed as STUMP. A benign metastasizing leiomyoma was highly suspected.

Methods. Clinical, pathologic, and radiologic characters of the patient with STUMP confined within the lumbar spine were retrospectively reviewed. A mini review was also conducted.

Results. We describe the first spine-confined case of STUMP.

Conclusion. Significant new information in the growing literature of this rare and newly identified diagnosis has addressed the need for orthopedists to consider the STUMP diagnosis.

Supplemental Digital Content is available in the text.A 47-year-old woman with low back pain, left thigh pain, and numbness of left extremity was found to have osteolytic lesions in second and fourth lumbar vertebral bodies. The case was subsequently confirmed as the first smooth muscle tumor of uncertain malignant potential isolated involving spine. Benign metastasizing leiomyosarcoma as an extremely rare variant of smooth was highly suspected.

From the Orthopaedic Department, Huashan Hospital, Fudan University, Shanghai, China

Address correspondence and reprint requests to Jian-yuan Jiang, MD, Orthopaedic Department, Hua Shan Hospital, Fu Dan University, No. 12 Middle Urumchi St, Shanghai, China 200040; E-mail:

Acknowledgment date: April 3, 2011. Acceptance date: July 19, 2011.

The manuscript submitted does not contain information about medical device(s)/drug(s).

No funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

© 2012 Lippincott Williams & Wilkins, Inc.