The association between lumbar facet joint inflammation and radiculopathy was investigated using behavioral, histologic, and immunohistochemical testing in rats.
To develop a rat model of lumbar facet joint inflammation and ascertain whether facet joint inflammation induces radiculopathy using this model.
Both mechanical and chemical factors have been identified as important for inducing radiculopathy. In lumbar spondylosis, facet joint osteophytes may contribute to nerve root compression, which may induce radiculopathy. Furthermore, inflammation may occur in the facet joint, as in other synovial joints. Inflamed synovium may thus release inflammatory cytokines and induce nerve root injury with subsequent radiculopathy.
A piece of gelatin sponge containing complete adjuvant was inserted into the L5–L6 facet joint in rats (arthritis group). Saline was used in the control group. Mechanical allodynia was determined using the von Frey test. Inflammatory cells infiltrating the epidural space were counted, and changes in cartilage were assessed histologically. Tumor necrosis factor (TNF)-α-immunoreactive cells in the L5 dorsal root ganglion were counted.
Mechanical allodynia was observed in the arthritis group from day 3, gradually recovering during the observation period. Significantly larger numbers of inflammatory cells had infiltrated the epidural space by days 3 and 7 in the arthritis group than in controls. Numbers of TNF-α-immunoreactive cells were significantly increased at days 1 and 3 in the arthritis group compared with controls. Predominantly small nociceptive neurons were stained.
When inflammation was induced in a facet joint, inflammatory reactions spread to nerve roots, and leg symptoms were induced by chemical factors. These results support the possibility that facet joint inflammation induces radiculopathy.
The association between lumbar facet joint inflammation and radiculopathy was investigated using histologic, immunohistochemical, and behavioral testing in rats. When inflammation was induced in a facet joint, the inflammatory reaction spread to nerve roots and leg symptoms were induced by chemical factors. Facet joint inflammation might induce radiculopathy.
From the Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.
Acknowledgment date: December 7, 2005. First revision date: April 3, 2006. Second revision date: May 15, 2006. Acceptance date: May 15, 2006.
Supported by grants from the Fukushima Society for the Promotion of Medicine.
The manuscript submitted does not contain information about medical device(s)/drug(s).
Foundation funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.
Address correspondence and reprint requests to Hisayoshi Tachihara, MD, Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1-Hikarigaoka, Fukushima City, Fukushima 960-1295, Japan; E-mail: firstname.lastname@example.org