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Primary Solitary Cervical Amyloidosis: Case Report and Review of the Literature

Iplikcioglu, A Celal, MD*; Bek, Sirzat, MD*; Gokduman, Cem A., MD*; Cosar, Murat, MD*; Sav, Aydn, MD†ı

doi: 10.1097/01.brs.0000251016.54203.71
Case Report

Study Design. A case report and literature review are presented.

Objective. To describe and review the clinical presentations, characteristic findings from imaging studies, types, differential diagnosis, prognosis, and treatment of amyloidoma arising within the vertebrae.

Summary of Background Data. Amyloidoma can occur in the bone, skin, larynx, lymph nodes, urinary bladder, eye, tongue, and gastrointestinal system. However, amyloidomas affecting the vertebral bones are very rare. To our knowledge, only 3 cases of amyloidoma involving cervical spine have been reported previously.

Methods. In this report, we present a case of solitary amyloidosis of the cervical spine.

Results. The differential diagnosis of primary solitary spinal amyloidoma includes metastasis, infection, primary bone tumors, plasmocytoma, and Potts abscess. The correct diagnosis can be achieved only after the specific staining of tissue. The prognosis of amyloidosis is related to the specific form of amyloidosis. However, primary solitary amyloidosis has the best prognosis, although a limited number of patients without long-term follow-up studies have been reported.

Conclusions. Primary solitary amyloidosis is a rare form of the amyloidosis, which is different from the other forms of amyloidosis because of excellent prognosis with surgical excision. Combined surgical excision and spinal stabilization is the best treatment.

Primary solitary amyloidosis is a rare form of amyloidosis characterized by focal occurrence, not secondary to a systemic process of plasma cell dyscrasia or abnormal serum proteins. However, amyloidomas affecting the vertebral bones are very rare. In this report, we present a case of solitary amyloidosis of the cervical spine.

From the *Neurosurgery Clinic, Ministry of Health Okmeydani Teaching and Research Hospital; and †Department of Neuropathology, Marmara University, Basibuyuk-Maltepe, Istanbul, Turkey.

Acknowledgment date: March 30, 2006. First revision date: August 12, 2006. Acceptance date: August 14, 2006.

The manuscript submitted does not contain information about medical device(s)/drug(s).

No funds were received in support of this work. No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this manuscript.

Address correspondence and reprint requests to Sirzat Bek, MD, ATA 2 Sitesi B6 2B D:9, Cengelkoy, Istanbul, Turkey; E-mail:

© 2007 Lippincott Williams & Wilkins, Inc.