Study Desing
This study analyzed the mode of inheritance of ossification of the posterior longitudinal ligament (OPLL) from the pedlgree of a femily.
Objectives
The results were correlated to provide a new mode of inheritance of OPLL.
Summary of Background Data
Although a nationwide multicenter survey of OPLL has been carried out in 347 subjects and 1030 relatives in Japan since 1981, no parental consanguinity has been reported.
Methods
In the family, three siblings and one other member of a family underwent operations for OPLL in our department, and the clinical information regarding other family members was obtained from interviews with these four patients or relatives.
Results
The parents of three affected siblings and another unaffected sister were first cousins, and the father was suspected to be affected as well.
Conclusion
Transmission of OPLL as an autosomal recessive trait in this family, which has not been reported is suspected; although, the possibility that it is dominant trait can not be excluded.
