TechniquesBiological Augmentation of Rotator Cuff Repair Platelet-rich Plasma (PRP) and Bone Marrow Aspirate (BMA)Singh, Hardeep MD*; Voss, Andreas MD*; Mazzocca, Augustus D. MD*; Virk, Mandeep S. MD†Author Information *Department of Orthopaedic Surgery, New England Musculoskeletal Institute, University of Connecticut School of Medicine, Farmington, CT †Department of Orthopaedic Surgery, Division of Shoulder and Elbow Surgery, NYU Langone Medical Center, NYU Hospital for Joint Diseases, New York, NY A.D.M.: consulting and research support from Arthrex. The other authors declare no conflict of interest. Reprints: Mandeep S. Virk, MD, Department of Orthopaedic Surgery, Division of Shoulder and Elbow Surgery, NYU Langone Medical Center, NYU Hospital for Joint Diseases, 355 West 52nd Street, Third Floor, New York, NY 10019 (e-mail: [email protected]). Techniques in Shoulder & Elbow Surgery: December 2015 - Volume 16 - Issue 4 - p 107-114 doi: 10.1097/BTE.0000000000000059 Buy Metrics Abstract Biological therapies that can augment tendon to bone healing are desirable for the management of clinical conditions such as failed rotator cuff (RC) repair, chronic retracted RC tears, and RC tears in a compromised host (smokers, chronic medical conditions including diabetes). Bone marrow aspirate and platelet-rich plasma are 2 autologous biological therapies that are currently being used clinically to augment tendon to bone healing. The indications for this biological therapy, its efficacy, duration, dosage, and optimum cellular concentration are in the process of evolution and require continued ongoing investigations for further optimization. In this technique article, we describe the biological basis and our technique for the preparation and use of platelet-rich plasma and bone marrow aspirate for augmentation of RC repair. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.