PHARMACOGENOMICS AND PROTEOMICS: ENABLING THE PRACTICE OF PERSONALIZED MEDICINE AMERICAN
Editors: Steven H.Y. Wong, PhD, Mark W. Linder, PhD; Roland Valdes Jr., PhD
Bibliographic Data: Association for Clinical Chemistry, Inc., 2006. ISBN: 1-59425-046-4, 409 pages, soft cover, $135.00.
Reviewer's Expert Opinion
Description: This is a current snapshot of the rapidly evolving field and clinical applications of pharmacogenomics and proteomics. Purpose: The purpose of this book is to provide a compendium of current information about the applications of pharmacogenetics and proteomics and their role in personalized medicine. This is a worthy objective, given the rapid evolution of this field and need for a reference compilation of this information. The authors have successfully achieved their purpose. Audience: This book is written at a fairly high level and will appeal most to those actually working in the areas of genomics, pharmacogenetics, or proteomics-practicing clinical laboratory scientists, pathologists, pathology and laboratory medicine residents, fellows, pharmacists, research laboratories, manufacturers developing or marketing assays, and regulators involved in reviewing such assays for approval. The authors are credible authorities in their fields. Features: This full-sized paperback book contains a wealth of information about the rapidly evolving fields of pharmacogenomics and proteomics. The book is written at a fairly sophisticated level, most appropriate for those working directly in this area (beginners will undoubtedly find it interesting but will have considerable genomics jargon to master). The book is divided into four major sections: an introductory and background section, methodologies and techniques, selected clinical applications, and emerging biotechnologies. I am not current in this area and find this book absolutely fascinating and the right one to bring me up to speed. Although I fully expect pharmacogenomics to revolutionize how we choose which drug to prescribe to which patient, I have never thought that pharmacogenomics can also help solve unexplained deaths (i.e., forensic pharmacogenomics)-wow! There were many more applications than those with which I was familiar, so this book was a real eye opener. The major missing piece was discussion about standardization of this testing across multiple laboratories and manufacturer platforms. How can the consumer be assured that a result from one laboratory will be reliably obtained by another? This is a topic of significant controversy today among the international community, and it will be interesting to have a discussion of these issues.
Assessment: This is a great book that presents, in a single place, a nice assortment of articles and topics representative of the rapidly evolving field of pharmacogenomics and proteomics. This is a great book if you want to update your knowledge in this area.
Valerie L. Ng, PhD, MD
(Alameda County Medical Center/Highland Hospital)