Evolving Concepts in Sepsis and Septic Shock Editors: Peter Q. Eichacker, MD; Jerome Pugin, MD Bibliographic Data: Kluwer Academic Publishers, 2001. ISBN: 0-7923-7235-2, Series Title: Perspectives on Critical Care Infectious Diseases, v. 3, 195 pp, hard cover, $165.00.
Reviewer's Expert Opinion:
This book, part of the Perspectives on Critical Care: Infectious Diseases series, covers the conceptual and therapeutic advances in the management of severe infections.
Insight into interesting and potentially useful developments in the field of sepsis are provided.
Investigators and teachers with an interest in infection and its multiple manifestations are an appropriate audience for this work. Contributors represent an international group of authorities involved in clinical and preclinical trials of new sepsis strategies.
The initial theme discussed is the difficulty surrounding identification of patients warranting intervention for sepsis. The susceptibility to sepsis and the genetics of recently described receptor systems is then covered. The final group of chapters describe a number of investigational therapies for sepsis including corticosteroids, antiinflammatory therapies, and immunostimulants including granulocyte colony stimulating factor. Chapters are clearly written and abundantly referenced with citations dating to within one year of publication. For the most part, citations represent original work. There are no illustrations and only a small number of line drawings and tables. The table of contents provides chapter title and authorship. A subject index of six pages concludes. Twelve chapters are included in the approximately 200 pages of this attractive book.
This book provides a concise update on many of the treatment strategies at the center of contemporary clinical trials in sepsis. Presentations on the new genetics of infection and the continuing question of the role of steroids in sepsis are particularly helpful. The continuing problems of antiinflammatory trials in sepsis are also discussed.