∗Department of Emergency Medicine, University of Minnesota, Minneapolis, Minnesota
†Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, Minnesota
‡The NMR Metabolomics Laboratory and the Department of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan
§Michigan Regional Comprehensive Metabolomics Resource Core ((MRC)2), Ann Arbor, Michigan
||Department of Computational Medicine and Bioinformatics, School of Medicine, University of Michigan, Ann Arbor, Michigan
¶Department of Emergency Medicine, University of Mississippi Medical Center, Jackson, Mississippi
∗∗Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
††Michigan Center for Integrative Research in Critical Care (MCIRCC), School of Medicine, University of Michigan, Ann Arbor, Michigan
Address reprint requests to Michael A. Puskarich, MD, MS, Department of Emergency Medicine Univeristy of Minnesota 717 Delaware St SE Minneapolis MN 55414 E-mail: [email protected]
Received 1 July, 2020
Revised 22 July, 2020
Accepted 27 October, 2020
Study concept and design: MAP, AEJ, KAS; oversight of metabolomics data generation: KAS; generation of quantitative NMR metabolomics data: CM, TLF; analysis data and statistical analyses: MAP; data interpretation: MAP, AEJ, KAS; drafting of the manuscript and its revision for important intellectual content: MAP, CM, TLF, AK, AEJ, KAS; final approval of the version submitted for publication: MAP, CM, TLF, AK, AEJ, KAS.
This study was supported by the National Institute of General Medical Sciences (NIGMS) K23GM113041 (MAP), R01GM103799 (AEJ), and R01GM111400 (KAS). The content is solely the responsibility of the authors and does not necessarily represent the official views of NIGMS or the NIH.
The authors report no conflicts of interest.
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