CASE PRESENTATIONPulmonary co-infection with Cryptococcus neoformans and Mycobacterium tuberculosis in a middle-aged male, case report and literature reviewChen, Hanlua; Qiu, Chunningb; Cen, Keb; Wu, Shenghaia,b Author Information aThe 4th Clinical Medical College, Zhejiang Chinese Medical University bDepartment of Laboratory, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine Zhejiang, China. Correspondence to Shenghai Wu, Affiliated Hangzhou First People's Hospital, 261 Huansha Road, Shangcheng District, Hangzhou, Zhejiang, China. E-mail: [email protected] Received 26 March, 2022 Accepted 19 April, 2022 Reviews and Research in Medical Microbiology ():10.1097/MRM.0000000000000315, December 07, 2022. | DOI: 10.1097/MRM.0000000000000315 Buy PAP Metrics Abstract Co-infection with Cryptococcus neoformans and Mycobacterium tuberculosis is rare, especially in people with normal immune function. We present a case of a middle-aged man with tuberculosis complicated with cryptococcal pneumonia. He was admitted for chest distress, productive cough with white sputum and fever. The diagnosis was based on the positive detection of Mycobacterium tuberculosis RNA in bronchoalveolar lavage fluid (BALF), positive T-SPOT by ESAT-6 and finding Cryptococcus neoformans in BALF culture. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.