Univited Review Article: PDF OnlyAssessment of different laboratory tests for the diagnosis of novel coronavirus infectionsGhojoghi, Rozitaa,b,*; Zamani, Bahareha,c,*; Behbahani, Abbas Behzada Author Information aDiagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences bDepartment of Bacteriology and Virology, School of Medicine cDepartment of Medical Biotechnology and Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. *R.G. and B.Z. share co-first authorship. Correspondence to Abbas Behzad Behbahani, PhD, Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Tel: +98 917 120 1125; e-mail: [email protected] Received 14 November, 2020 Revised 19 January, 2021 Accepted 16 February, 2021 Reviews and Research in Medical Microbiology: April 09, 2021 - Volume - Issue - doi: 10.1097/MRM.0000000000000285 Free PAP Metrics Abstract Rapid diagnosis of coronavirus disease 2019 (COVID-19)-infected patients is urgent in making decisions on public health measures. There are different types of diagnostic tests, such as quantitative PCR assay, antibody, and antigen-based and CRISPR-based tests, which detect genetic materials, viral proteins, or human antibodies in clinical samples. However, the proper test should be highly sensitive, quick, and affordable to address this life-threatening situation. This review article highlights the advantages and disadvantages of each test and compares its different features, such as sensitivity, specificity, and limit of detection to reach a reliable conclusion. Moreover, the FDA-authorized kits and studies’ approaches toward these have been compared to provide a better perspective to the researchers. Copyright © Wolters Kluwer Health, Inc. All rights reserved.