MICROBIOLOGYThe role of plants and macrofungi as a source of novel antimicrobial agentsNelson, David W.a; Millar, Beverley C.b,c,d; Rao, Juluri R.a; Moore, John E.b,c,d Author Information aPlant Pathology, AgriFood & Biosciences Institute (AFBI), Belfast bSchool of Biomedical Sciences, Ulster University, Coleraine cNorthern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital dCentre for Experimental Medicine, Queen's University, Belfast, UK. Correspondence to John E. Moore, Laboratory for Disinfection and Pathogen Elimination Studies, Northern Ireland Public Health Laboratory, Nightingale (Belfast City) Hospital, Belfast BT9 7AD, UK. E-mail: [email protected] Received 19 January, 2021 Accepted 25 January, 2021 Reviews in Medical Microbiology: October 2021 - Volume 32 - Issue 4 - p 231-236 doi: 10.1097/MRM.0000000000000272 Buy Metrics Abstract Antibiotic resistance presents a significant challenge to clinical, veterinary and plant health and is now recognized by the WHO as a major emerging problem of global significance. Recently, there has been a paucity of new antibiotics being developed, thus refocussing investigations into natural antimicrobials, especially from plants. Historically, plants have been a rich source of medicines, ranging from chemotherapeutic compounds, anti-inflammatories to antimicrobial agents, where such therapeutic activity has been recognized and exploited by traditional medicine in many countries, particularly in Asia. This review wishes to explore the substances in plants which are antimicrobial and to identify their broad spectrum of activity. In addition, the review discusses the ecological effects of overharvesting of medicinal plants and the consequences for species survival. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.