The aim of this study was assessment the association of human leukocyte antigen (HLA) alleles and extrapulmonary tuberculosis (EPTB).
One-hundred whole blood samples were collected from patients with EPTB (n = 50) and healthy control patients (n = 50). The sequence-specific oligonucleotide was used for HLA-DRB1 genotyping.
The HLA-DRB1∗7 (relative risk = 4.35) and HLA-DRB1∗3 (relative risk = 3.20) genotypes were significantly more frequent among patients with EPTB compared with healthy subjects (38 vs. 16%, P = 0.002 and 27 vs. 8%, P = 0.002, respectively). The total alleles of the HLA-DRB1 were more common among female patients (60%) vs. male patients (40%). From the result of HLA-DRB1 genotypes, most of the females had two alleles, whereas males mostly had one allele. The frequency of the HLA-DRB1∗3 and HLA-DRB1∗7 was significantly more common in female patients (72 and 62%, respectively), than male patients (28 and 38%, respectively). Moreover, this result was observed for the genotype HLA-DRB1∗15.
The association of the HLA-DRB1∗3 and the HLA-DRB1∗7 genotypes with the EPTB was observed in this study, albeit needing more verifications. Furthermore, the HLA-DRB1∗315 was more frequent among healthy subjects. More investigations are also essential to confirm the difference between male and female patients with the EPTB regarding the rate of HLA genotypes.