BACTERIOLOGYContribution of aging oral microbiota in getting neurodegenerative diseasesKarbalaei, Mohsena; Keikha, Masoudb; Yousefi, Bahmanc; Ali-Hassanzadeh, Mohammadd; Eslami, MajideAuthor Information aDepartment of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft bStudent Research Committee, Mashhad University of Medical Sciences, Mashhad cDepartment of Immunology, Semnan University of Medical Sciences, Semnan dDepartment of Immunology, School of Medicine, Jiroft University of Medical Sciences, Jiroft eCancer Research Center, Semnan University of Medical Sciences, Semnan, Iran. Correspondence to Majid Eslami, Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran. Tel: +98 9144078609; e-mail: [email protected] Received 29 February, 2020 Revised 15 April, 2020 Accepted 27 May, 2020 Reviews in Medical Microbiology: April 2021 - Volume 32 - Issue 2 - p 90-94 doi: 10.1097/MRM.0000000000000245 Buy Metrics Abstract Nowadays aging-related neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease are as important as infectious diseases for human communities. 60–80% of dementia cases are related to Alzheimer's disease while only 2–3% of cases are associated with Parkinson's disease. Oral bacteria produce some chemical compounds such as volatile sulfur compounds and therefore are responsible for halitosis (malodor). This is while most of the cases (80–90%) of halitosis caused following the production of volatile sulfur compounds in the oral cavity. Some periodontal pathogens such as Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Prevotella gingivalis are detectable in Alzheimer's patients. On the other hand, Prevotella genus members, (e.g., P. intermedia, P. nigrescens, and P. melaninogenica) increase in Parkinson's disease patients, and most likely, it is associated with a reduction in hygiene oral care. Although many aspects of these diseases are still unknown, we have studied the Alzheimer's disease and Parkinson's disease diseases and also the role of oral microbiota infections in these diseases in older persons. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.