BACTERIOLOGYEucalyptus camaldulensis efficiency for application against microbial infectionsTalha, Mustafa H.a; Alnomani, Yaqdhanb; Mirforughi, Seyede A.bAuthor Information aDepartment of Biology, College of Science, Mustansiryah University, Baghdad bDepartment of Medical Laboratory Techniques, Najaf Islamic University, Najaf, Iraq. Correspondence to Yaqdhan Alnomani, Medical Laboratory Techniques, Najaf Islamic University, Najaf, Iraq. Tel: +964 21324972; e-mail: [email protected] Received 27 March, 2019 Revised 1 December, 2019 Accepted 21 February, 2020 Reviews in Medical Microbiology: January 2021 - Volume 32 - Issue 1 - p 1-5 doi: 10.1097/MRM.0000000000000234 Buy Metrics Abstract On account of the continuing increase in antimicrobial resistance among infectious agents which are mostly life-threatening, seeking novel and alternative therapeutic approaches seems essential. Eucalyptus camaldulensis, generally known as eucalyptus, contains various healing traits such as antimicrobial characteristics. These herbs generally grow alongside the rivers with both continuous and seasonal water. The antimicrobial applications of this herb, particularly against pandrug and multidrug resistant microorganisms mostly attributed to phenolic, polar terpene compounds and spathulenol. Major bioactive antimicrobial fractions include flavonoids, alkaloids, pigments, terpenes, phenolics, starches, steroids and essential oils. E. camaldulensis has antimicrobial features against various bacterial (both Gram-positive and Gram-negative species), fungal, parasitic and viral infections. Regarding molecular mechanisms, the discharge of Gram-negative outer membrane lipopolysaccharide and increase the permeability of the cytoplasmic membrane have been proposed. Leaf extracts might be a good source of antibacterial and antifungal materials that might be useful in pharmaceutical industry. Interactions with various conventional antimicrobial agents providing synergistic effects suppose a variety of antimicrobial mechanisms by fractions remaining to be entirely elucidated. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.