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Inhibitory effects of curcumin on sequel of infections and their signaling pathways

a review

Shahcheraghi, Seyed H.a,b; Ayatollahi, Jamshidb; Lotfi, Marziehc

Reviews in Medical Microbiology: April 2019 - Volume 30 - Issue 2 - p 113–121
doi: 10.1097/MRM.0000000000000159
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Curcumin, a bright yellow chemical produced by some plants (turmeric) that are member of the ginger family, is cultivated in tropical regions of Asia. It has many impacts, including antimicrobial, anticarcinogenic, anti-inflammatory, and antioxidant. Different databases such as PubMed, Scopus, Google Scholar, and Web of Science with keywords of ‘Curcumin’, ‘anti-microbial’, ‘anti-fungal’, ‘anti-parasitic’, ‘anti-viral’, ‘Infection’, ‘Pathogen’, ‘anti-bacterial’, and ‘Herbal Drug’ have been considered in this search without publication time limitation. This study reviewed the inhibitory effects of curcumin on infections. Based on these studies, the plant drug of curcumin is a therapeutic effective agent for the advancement of treatment against the types of pathogens including bacteria, viruses, parasites, and fungi. Nevertheless, it seems that be essential for more researches, especially about parasites and fungi that have been performed fewer studies about the effect of curcumin on them. Curcumin exerts its effects on sequel of infections and their agents via influence on signaling pathways, cell cycle, drug synergism, inducing apoptosis and inhibition of virulence factors.

aDepartment of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad

bInfectious Diseases Research Center, Shahid Sadoughi University of Medical Sciences

cDepartment of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Correspondence to Seyed H. Shahcheraghi, Infectious and Tropical Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran. Tel: +98 9132531389; e-mail: shahcheraghih@gmail.com

Received 15 July, 2018

Accepted 16 October, 2018

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